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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Preferred Name | betahistine | |
| Synonyms |
2-(beta-methylaminoethyl)pyridine betahistine 2-[2-(methylamino)ethyl]pyridine N-methyl-2-pyridineethanamine betahistinum betahistina N-methyl-2-pyridin-2-ylethanamine N-methyl-2-(2-pyridinyl)ethanamine C8H12N2 methyl[2-(pyridin-2-yl)ethyl]amine [2-(2-pyridyl)ethyl]methylamine |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_35677 |
|
| activates | ||
| AHFScode |
92:00.00
|
|
| ATCCode |
N07CA01
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|
| binds | ||
| blocks | ||
| CASRN |
5638-76-6
|
|
| DBBrand |
serc
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|
| DBname |
betahistine
|
|
| Definition |
An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.
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|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000584 |
|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
|
|
| InChIKey |
InChIKey=UUQMNUMQCIQDMZ-UHFFFAOYSA-N
|
|
| label |
betahistine
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|
| modulates | ||
| prefixIRI |
obo2:CHEBI_35677
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|
| prefLabel |
betahistine
|
|
| SMILES |
CNCCc1ccccn1 CNCCC1=CC=CC=N1
|
|
| Synonym |
2-(beta-methylaminoethyl)pyridine betahistine 2-[2-(methylamino)ethyl]pyridine N-methyl-2-pyridineethanamine betahistinum betahistina N-methyl-2-pyridin-2-ylethanamine N-methyl-2-(2-pyridinyl)ethanamine C8H12N2 methyl[2-(pyridin-2-yl)ethyl]amine [2-(2-pyridyl)ethyl]methylamine
|
|
| xref |
ChemSpider:2276 PharmGKB:PA165958372 Wikipedia:Betahistine CiteXplore:7589314 CASRN:5638-76-6 CiteXplore:22365373 PubChem Compound:2366 KEGG DRUG:D07522 NIST Chemistry WebBook:5638-76-6 PubChem Substance:99443252 HMDB:HMDB15644 Beilstein:112294 Wikipedia:http://en.wikipedia.org/wiki/Betahistine Reaxys:112294 CiteXplore:20530654 ChEMBL:132459 DrugBank:DB06698 ChEBI:35677 CiteXplore:22745706
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| subClassOf |
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