loading...| Preferred Name |
carbidopa |
|
| Synonyms |
C10H16N2O5 (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1) (S)-carbidopa hydrate L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate carbidopa monohydrate (S)-(-)-carbidopa hydrate carbidopum monohydricum carbidopa hydrate carbidopa (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_3395 |
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| altId |
CHEBI:212626 |
|
| CASRN |
28860-95-9 |
|
| DBBrand |
atamet lodosyn hmd lodosin |
|
| DBname |
carbidopa |
|
| DBSynonym |
alpha-methyldopahydrazine n-aminomethyldopa carbidopa monohydrate carbidopum [inn-latin] carbidopa anhydrous c-dopa mk-486 |
|
| Definition |
The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. |
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| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_48560 http://purl.obolibrary.org/obo/CHEBI_66956 |
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| InChI |
InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1 |
|
| InChIKey |
InChIKey=QTAOMKOIBXZKND-PPHPATTJSA-N |
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| inhibits | ||
| label |
carbidopa |
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| prefixIRI |
obo2:CHEBI_3395 |
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| prefLabel |
carbidopa |
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| SMILES |
O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O O.C[C@@](CC1=CC(O)=C(O)C=C1)(NN)C(O)=O |
|
| Synonym |
C10H16N2O5 (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1) (S)-carbidopa hydrate L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate carbidopa monohydrate (S)-(-)-carbidopa hydrate carbidopum monohydricum carbidopa hydrate carbidopa (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate |
|
| xref |
Patent:GB940596 Drugs.com:http://www.drugs.com/cdi/carbidopa.html Wikipedia:http://en.wikipedia.org/wiki/Carbidopa Patent:DE2062285 PharmGKB:PA448794 DrugBank:DB00190 ChEBI:3395 RxList:http://www.rxlist.com/cgi/generic/sinemet.htm CASRN:38821-49-7 National Drug Code Directory:0056-0511-68 ChEMBL:774699 Patent:DE2062332 Patent:US3462536 ChEMBL:10841799 KEGG DRUG:D00558 |
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| subClassOf |