The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	bumetanide
Synonyms	3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid bumetanidum bumetanide 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid C17H20N2O5S bumetanida 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid
ID	http://purl.obolibrary.org/obo/CHEBI_3213
AHFScode	40:28.08
altId	CHEBI:239281
ATCCode	C03CA02
blocks	http://purl.obolibrary.org/obo/dinto_0341
CASRN	28395-03-1
DBBrand	fordiuran burine fontego lunetoron segurex burinex lixil bumex
DBname	bumetanide
DBSynonym	bumetanida [inn-spanish] bumetanidum [inn-latin]
Definition	4-Phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0001135 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_4037 http://purl.obolibrary.org/obo/dinto_1007 http://purl.obolibrary.org/obo/dinto_1147 http://purl.obolibrary.org/obo/dinto_0231
has role	http://purl.obolibrary.org/obo/CHEBI_35498
InChI	InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
InChIKey	InChIKey=MAEIEVLCKWDQJH-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2116
inhibits	http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_1977 http://purl.obolibrary.org/obo/dinto_1975 http://purl.obolibrary.org/obo/dinto_4037 http://purl.obolibrary.org/obo/dinto_1007 http://purl.obolibrary.org/obo/dinto_4301 http://purl.obolibrary.org/obo/dinto_1147 http://purl.obolibrary.org/obo/dinto_0231 http://purl.obolibrary.org/obo/dinto_0520
is transported by	http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_1987
label	bumetanide
may interact with	http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_9352 http://purl.obolibrary.org/obo/CHEBI_49662 http://purl.obolibrary.org/obo/CHEBI_31468 http://purl.obolibrary.org/obo/dinto_DB01172 http://purl.obolibrary.org/obo/CHEBI_5855 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/dinto_DB00798 http://purl.obolibrary.org/obo/CHEBI_17076 http://purl.obolibrary.org/obo/dinto_DB00955 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB00684 http://purl.obolibrary.org/obo/dinto_DB01404 http://purl.obolibrary.org/obo/dinto_DB01396 http://purl.obolibrary.org/obo/CHEBI_2637 http://purl.obolibrary.org/obo/CHEBI_27899
prefixIRI	obo2:CHEBI_3213
prefLabel	bumetanide
SMILES	CCCCNC1=C(OC2=CC=CC=C2)C(=CC(=C1)C(O)=O)S(N)(=O)=O CCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O
Synonym	3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acid bumetanidum bumetanide 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid 3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid C17H20N2O5S bumetanida 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid
xref	ChemSpider:2377 ChEBI:3213 ChEMBL:18374572 CASRN:28395-03-1 Patent:DE1964504 Patent:US3806534 PharmGKB:PA448682 BindingDB:25903 Drugs.com:http://www.drugs.com/cdi/bumetanide.html PubChem Substance:46508147 Beilstein:2185351 ChEMBL:3989818 Wikipedia:http://en.wikipedia.org/wiki/Bumetanide Drugs Product Database (DPD):728284 DrugBank:DB00887 Wikipedia:Bumetanide PubChem Compound:2471 National Drug Code Directory:0004-0125-01 RxList:http://www.rxlist.com/cgi/generic2/bumetan.htm KEGG DRUG:D00247 Patent:DE1964503 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/bum1058.shtml
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_3213	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3213	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3213	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3213	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3213	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/XCO_0000925	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3213	CHEBI	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2219	OCHV	LOOM
http://purl.obolibrary.org/obo/CHEBI_3213	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3213	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3213	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3213	DRON	LOOM
http://www.drugbank.ca/drugs/DB00887	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0006376	OCHV	LOOM
https://go.drugbank.com/drugs/DB00887	MDM	LOOM
http://purl.bioontology.org/ontology/VANDF/4017794	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/C03CA02	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.127.020.452.500	RH-MESH	LOOM
http://purl.bioontology.org/ontology/CSP/2840-3310	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.100.050.300.200	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDDF/002312	NDDF	LOOM
http://purl.jp/bio/4/id/200906082003803921	IOBC	LOOM
http://purl.bioontology.org/ontology/SNMI/C-72020	SNMI	LOOM
http://stirdf.jst.go.jp/id/200907027423743900	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.150	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/1808	RXNORM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015950	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/OMIT_0003385	OMIT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387498005	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.150	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002034	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D002034	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/LP16052-0	LOINC	LOOM
http://www.co-ode.org/ontologies/galen#Bumetanide	GALEN	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146155	NDFRT	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0006376	HFO	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000788832	PDQ	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006833	LOINC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28875	NCIT	LOOM
http://purl.bioontology.org/ontology/RCD/b32..	RCD	LOOM
http://purl.bioontology.org/ontology/MESH/D002034	MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C28875	BERO	LOOM