The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

pitavastatin
Synonyms

NK-104

pitavastatine

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid

pitavastatinum

NK 104

C25H24FNO4

pitavastatia

pitavastatin

ID

http://purl.obolibrary.org/obo/CHEBI_32020

AHFScode

24:0608

ATCCode

C10AA08

binds

http://purl.obolibrary.org/obo/dinto_4019

http://purl.obolibrary.org/obo/dinto_3582

http://purl.obolibrary.org/obo/dinto_0217

http://purl.obolibrary.org/obo/dinto_1890

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_1974

http://purl.obolibrary.org/obo/dinto_0887

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_2019

http://purl.obolibrary.org/obo/dinto_1824

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_1322

CASRN

147511-69-1

DBBrand

livalo

DBSalt

pitavastatin calcium

Definition

A dihydroxy monocarboxylic acid that is (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]hept-6-enoic acid in which the two hydroxy groups are located at positions 3 and 5 (the 3R,5S-stereoisomer). Used as its calcium salt for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.

Pitavastatin a lipid-lowering agent that belongs to the statin class of medications for treatment of dyslipidemia. It is also used for primary and secondary prevention of cardiovascular disease. FDA approved in Aug 3, 2009.

has effect

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0001378

http://purl.obolibrary.org/obo/OAE_0001365

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000613

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000336

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0001364

has pharmacological target

http://purl.obolibrary.org/obo/dinto_4019

has role

http://purl.obolibrary.org/obo/CHEBI_35664

http://purl.obolibrary.org/obo/CHEBI_22586

http://purl.obolibrary.org/obo/CHEBI_35821

InChI

InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1

InChIKey

InChIKey=VGYFMXBACGZSIL-MCBHFWOFSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_4019

is metabolised by

http://purl.obolibrary.org/obo/dinto_1890

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_1221

is substrate of

http://purl.obolibrary.org/obo/dinto_3582

http://purl.obolibrary.org/obo/dinto_0217

http://purl.obolibrary.org/obo/dinto_1890

http://purl.obolibrary.org/obo/dinto_1892

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_1974

http://purl.obolibrary.org/obo/dinto_0887

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_2019

http://purl.obolibrary.org/obo/dinto_1824

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_1322

is transported by

http://purl.obolibrary.org/obo/dinto_1974

http://purl.obolibrary.org/obo/dinto_0887

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_2019

http://purl.obolibrary.org/obo/dinto_1824

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_1322

label

pitavastatin

may interact with

http://purl.obolibrary.org/obo/CHEBI_5001

http://purl.obolibrary.org/obo/CHEBI_5296

http://purl.obolibrary.org/obo/CHEBI_37924

http://purl.obolibrary.org/obo/CHEBI_4031

http://purl.obolibrary.org/obo/dinto_DB01394

http://purl.obolibrary.org/obo/dinto_DB01601

http://purl.obolibrary.org/obo/CHEBI_15940

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/CHEBI_28077

prefixIRI

obo2:CHEBI_32020

prefLabel

pitavastatin

SMILES

O[C@H](C[C@H](O)\C=C\C1=C(N=C2C=CC=CC2=C1C1=CC=C(F)C=C1)C1CC1)CC(O)=O

O[C@H](C[C@H](O)\\C=C\\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC(O)=O

Synonym

NK-104

pitavastatine

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid

pitavastatinum

NK 104

C25H24FNO4

pitavastatia

pitavastatin

xref

CiteXplore:22345687

CiteXplore:23161429

CiteXplore:22679249

Wikipedia:Pitavastatin

HMDB:HMDB41991

Wikipedia:http://en.wikipedia.org/wiki/Pitavastatin

CASRN:147511-69-1

CiteXplore:22472908

CiteXplore:22850760

CiteXplore:22077103

ChEBI:32020

KEGG COMPOUND:C13334

PharmGKB:PA142650384

National Drug Code Directory:0002-4771-90

CiteXplore:22361916

ChEMBL:775704

CiteXplore:22149769

CiteXplore:22878405

CiteXplore:22053916

CiteXplore:22884685

Patent:EP2141155

CiteXplore:22133277

CiteXplore:22520230

CiteXplore:22268518

CiteXplore:22332608

Drugs.com:http://www.drugs.com/ppa/pitavastatin.html

RxList:http://www.rxlist.com/livalo-drug.htm

CiteXplore:22356292

CiteXplore:22627182

CiteXplore:22807641

Patent:US2011269962

Patent:US2012016129

CiteXplore:21884024

CiteXplore:22410289

CiteXplore:21075465

Reaxys:7257773

CiteXplore:22948417

CiteXplore:23007012

CiteXplore:21585411

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

Delete Subject Author Type Created
No notes to display
Create mapping

Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_32020 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32020 DRON LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/443586000 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025448 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDDF/013206 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C108475 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907003401043739 IOBC LOOM
http://purl.jp/bio/4/id/200906058692132917 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/C10AA08 ATC LOOM
http://purl.bioontology.org/ontology/MESH/C108475 MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C87751 NCIT LOOM
http://purl.obolibrary.org/obo/NCIT_C87751 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_32020 DDSS LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C1101838 OCHV LOOM
http://www.drugbank.ca/drugs/DB08860 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000180308 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#54659 OCHV LOOM
https://go.drugbank.com/drugs/DB08860 MDM LOOM
http://purl.bioontology.org/ontology/VANDF/4029463 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/861634 RXNORM LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02125 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02125 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02125 MIO LOOM