The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	brimonidine
Synonyms	Bromoxidine Brimonidine brimonidine 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine C11H10BrN5 brimonidina 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline brimonidinum
ID	http://purl.obolibrary.org/obo/CHEBI_3175
activates	http://purl.obolibrary.org/obo/dinto_3877 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_1135
AHFScode	52:92.00
ATCCode	S01EA05
binds	http://purl.obolibrary.org/obo/dinto_3877 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_1135 http://purl.obolibrary.org/obo/dinto_0273
CASRN	59803-98-4
DBBrand	alphagan
DBname	brimonidine
DBSynonym	brimonidine tartrate bromoxidine
Definition	A quinoxaline derivative that has formula C11H10BrN5.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000838 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000549 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000937 http://purl.obolibrary.org/obo/OAE_0000612 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000587 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001382 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000329 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000313 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3877 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_1135
has role	http://purl.obolibrary.org/obo/CHEBI_35569 http://purl.obolibrary.org/obo/CHEBI_37886 http://purl.obolibrary.org/obo/CHEBI_35674
InChI	InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChIKey	InChIKey=XYLJNLCSTIOKRM-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_0273
is substrate of	http://purl.obolibrary.org/obo/dinto_0273
label	brimonidine
may interact with	http://purl.obolibrary.org/obo/CHEBI_71417 http://purl.obolibrary.org/obo/CHEBI_6838 http://purl.obolibrary.org/obo/CHEBI_4717 http://purl.obolibrary.org/obo/dinto_DB00780 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/dinto_DB01247 http://purl.obolibrary.org/obo/dinto_DB00752 http://purl.obolibrary.org/obo/CHEBI_63607 http://purl.obolibrary.org/obo/dinto_DB01171 http://purl.obolibrary.org/obo/CHEBI_63620 http://purl.obolibrary.org/obo/dinto_DB01037
modulates	http://purl.obolibrary.org/obo/dinto_3877 http://purl.obolibrary.org/obo/dinto_1581 http://purl.obolibrary.org/obo/dinto_1135
prefixIRI	obo2:CHEBI_3175
prefLabel	brimonidine
SMILES	Brc1c(NC2=NCCN2)ccc2nccnc12 BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12
Synonym	Bromoxidine Brimonidine brimonidine 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine C11H10BrN5 brimonidina 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline brimonidinum
xref	ChEMBL:162817 ChEBI:3175 KEGG COMPOUND:C07886 PubChem Substance:46507305 Drugs.com:http://www.drugs.com/cdi/brimonidine.html RxList:http://www.rxlist.com/cgi/generic3/alphagan-p.htm Guide To Pharmacology:520 IUPHAR:520 PharmGKB:PA448665 PubChem Compound:2435 Patent:US3890319 ChemSpider:2341 National Drug Code Directory:60758-866-05 DrugBank:DB00484 Wikipedia:Brimonidine KEGG DRUG:D07540 Patent:DE2309160 Wikipedia:http://en.wikipedia.org/wiki/Brimonidine Drugs Product Database (DPD):2243026 CASRN:59803-98-4 Beilstein:751629
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_3175	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3175	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_3175	CHEBI	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#38409	OCHV	LOOM
https://go.drugbank.com/drugs/DB00484	MDM	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022048	NDFRT	LOOM
http://www.drugbank.ca/drugs/DB00484	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0525227	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/134615	RXNORM	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00210	OCIMIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3175	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3175	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3175	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3175	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3175	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_3175	NIFSTD	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372547000	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/ATC/S01GA07	ATC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65269	NCIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4024043	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/S01EA05	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C015620	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C65269	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/D11AX21	ATC	LOOM