The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	betaxolol
Synonyms	betaxolol (3-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-2-hydroxypropyl)(propan-2-yl)amine 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol C18H29NO3 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol betaxololum
ID	http://purl.obolibrary.org/obo/CHEBI_3082
AHFScode	52:92.00
altId	CHEBI:101354
ATCCode	C07AB05 S01ED02
binds	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_3504 http://purl.obolibrary.org/obo/dinto_2651
blocks	http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_3504
CASRN	63659-18-7
DBBrand	kerlone betoptic betoptic s betaxon
DBname	betaxolol
DBSynonym	betaxololum [inn-latin] betaxolol hcl
Definition	3-Aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure.
has effect	http://purl.obolibrary.org/obo/OAE_0000238 http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000395 http://purl.obolibrary.org/obo/OAE_0001285 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000356 http://purl.obolibrary.org/obo/OAE_0000573 http://purl.obolibrary.org/obo/OAE_0000557 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001510 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001046 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000412 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0001370 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000935 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000426 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0001053 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0001063 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000405 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0001356 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0000514 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2907
has role	http://purl.obolibrary.org/obo/CHEBI_66991 http://purl.obolibrary.org/obo/CHEBI_35674 http://purl.obolibrary.org/obo/CHEBI_35530
InChI	InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
InChIKey	InChIKey=NWIUTZDMDHAVTP-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2993
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2993
is substrate of	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2993
label	betaxolol
may interact with	http://purl.obolibrary.org/obo/dinto_DB00912 http://purl.obolibrary.org/obo/CHEBI_28918 http://purl.obolibrary.org/obo/CHEBI_3650 http://purl.obolibrary.org/obo/CHEBI_5147 http://purl.obolibrary.org/obo/CHEBI_5441 http://purl.obolibrary.org/obo/CHEBI_49662 http://purl.obolibrary.org/obo/CHEBI_8249 http://purl.obolibrary.org/obo/CHEBI_149226 http://purl.obolibrary.org/obo/CHEBI_584020 http://purl.obolibrary.org/obo/dinto_DB00047 http://purl.obolibrary.org/obo/CHEBI_5855 http://purl.obolibrary.org/obo/CHEBI_9449 http://purl.obolibrary.org/obo/CHEBI_9445 http://purl.obolibrary.org/obo/dinto_DB00414 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_6804 http://purl.obolibrary.org/obo/dinto_DB00073 http://purl.obolibrary.org/obo/CHEBI_45979 http://purl.obolibrary.org/obo/dinto_DB00236 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_46631 http://purl.obolibrary.org/obo/CHEBI_8364 http://purl.obolibrary.org/obo/dinto_DB00816 http://purl.obolibrary.org/obo/CHEBI_64318 http://purl.obolibrary.org/obo/CHEBI_31654 http://purl.obolibrary.org/obo/CHEBI_4562
modulates	http://purl.obolibrary.org/obo/dinto_2907 http://purl.obolibrary.org/obo/dinto_3504
prefixIRI	obo2:CHEBI_3082
prefLabel	betaxolol
SMILES	CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1 CC(C)NCC(O)COC1=CC=C(CCOCC2CC2)C=C1
Synonym	betaxolol (3-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-2-hydroxypropyl)(propan-2-yl)amine 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol 1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-(propan-2-ylamino)propan-2-ol C18H29NO3 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanol betaxololum
xref	ChemSpider:2279 Wikipedia:http://en.wikipedia.org/wiki/Betaxolol National Drug Code Directory:0065-0245-20 Beilstein:1991268 PubChem Compound:2369 KEGG COMPOUND:C06849 ChEMBL:10891117 ChEBI:3082 PharmGKB:PA448611 Patent:DE2649605 Reaxys:1991268 ChEMBL:15993593 Wikipedia:Betaxolol Drugs Product Database (DPD):2235971 Drugs.com:http://www.drugs.com/cdi/betaxolol-drops.html RxList:http://www.rxlist.com/cgi/generic3/betaxolol.htm Patent:US4252984 CASRN:63659-18-7 Guide To Pharmacology:549 PubChem Substance:46506041 BindingDB:50026854 ChEMBL:1361581 IUPHAR:549 CiteXplore:1865331 KEGG DRUG:D07526 CiteXplore:2569884 ChEMBL:14971904 DrugBank:DB00195
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_3082	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3082	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3082	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3082	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3082	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3082	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3082	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3082	CHEBI	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1837	OCHV	LOOM
http://stirdf.jst.go.jp/id/200907081673812260	IOBC	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00567	OCIMIDO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015784	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Betaxolol	GALEN	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147726	ODAE	LOOM
http://purl.bioontology.org/ontology/LNC/LP70622-3	LOINC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147726	NDFRT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.063.624.698.077	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.755.624.698.077	RH-MESH	LOOM
http://www.drugbank.ca/drugs/DB00195	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0005320	OCHV	LOOM
http://purl.obolibrary.org/obo/MESH_D015784	BERO	LOOM
http://purl.obolibrary.org/obo/NCIT_C61652	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/S01ED02	ATC	LOOM
https://go.drugbank.com/drugs/DB00195	MDM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61652	NCIT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/409276006	SNOMEDCT	LOOM
http://purl.jp/bio/4/id/200906067467940507	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D015784	MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015691	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RXNORM/1520	NLMVS	LOOM
http://purl.bioontology.org/ontology/RXNORM/1520	RXNORM	LOOM
http://purl.bioontology.org/ontology/ATC/C07AB05	ATC	LOOM
http://purl.obolibrary.org/obo/OMIT_0016424	OMIT	LOOM
http://purl.obolibrary.org/obo/CHEBI_3082	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3082	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3082	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3082	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3082	ODNAE	LOOM
http://purl.bioontology.org/ontology/RCD/x01C0	RCD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.100.624.698.077	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4019633	VANDF	LOOM
http://purl.obolibrary.org/obo/CHEBI_3082	DRON	LOOM
http://purl.obolibrary.org/obo/ARO_3007750	ARO	LOOM