loading...| Preferred Name | benzatropine | |
| Synonyms |
3alpha-(diphenylmethoxy)tropane Benztropine 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane C21H25NO 3endo-benzhydryloxytropane benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether (1R,3R,5S)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane benzatropine (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane benzatropina tropine benzohydryl ether benzatropinum 3alpha-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_3048 |
|
| AHFScode |
28:36.08 |
|
| altId |
CHEBI:661238 |
|
| ATCCode |
N04AC01 |
|
| binds |
http://purl.obolibrary.org/obo/dinto_3343 http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_1071 |
|
| blocks | ||
| CASRN |
86-13-5 |
|
| DBBrand |
akitan cogentin apo-benztropine pms benztropine cobrentin cogentinol |
|
| DBname |
benzatropine |
|
| DBSynonym |
benzatropina [inn-spanish] benztropinum benzatropinum [inn-latin] tropine benzohydryl ether benzatropine mesilate benztropine benztropine mesylate |
|
| Definition |
Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments. |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0001167 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0001069 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000526 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000362 |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_66956 http://purl.obolibrary.org/obo/CHEBI_48876 |
|
| InChI |
InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+ |
|
| InChIKey |
InChIKey=GIJXKZJWITVLHI-PMOLBWCYSA-N |
|
| inhibits | ||
| is metabolised by | ||
| is substrate of | ||
| label |
benzatropine |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/CHEBI_8874 http://purl.obolibrary.org/obo/CHEBI_5613 http://purl.obolibrary.org/obo/CHEBI_53289 http://purl.obolibrary.org/obo/dinto_DB00427 |
|
| modulates | ||
| prefixIRI |
obo2:CHEBI_3048 |
|
| prefLabel |
benzatropine |
|
| SMILES |
[H][C@]1(C[C@]2([H])CC[C@]([H])(C1)N2C)OC(c1ccccc1)c1ccccc1 [H][C@]12CC[C@]([H])(C[C@@]([H])(C1)OC(C1=CC=CC=C1)C1=CC=CC=C1)N2C |
|
| Synonym |
3alpha-(diphenylmethoxy)tropane Benztropine 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane C21H25NO 3endo-benzhydryloxytropane benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether (1R,3R,5S)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane benzatropine (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane benzatropina tropine benzohydryl ether benzatropinum 3alpha-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane |
|
| xref |
DrugBank:DB00245 NIST Chemistry WebBook:86-13-5 Drugs Product Database (DPD):706531 ChEBI:3048 Drugs.com:http://www.drugs.com/cdi/benztropine.html RxList:http://www.rxlist.com/cgi/generic2/benztrop.htm Beilstein:90688 Wikipedia:http://en.wikipedia.org/wiki/Benztropine PharmGKB:PA448591 KEGG DRUG:D07511 KEGG COMPOUND:C06846 ChEMBL:775154 Wikipedia:Benzatropine National Drug Code Directory:0182-1299-89 CASRN:86-13-5 Patent:US2595405 |
|
| subClassOf |