The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

baclofen
Synonyms

baclofenum

beta-(Aminomethyl)-p-chlorohydrocinnamic acid

C10H12ClNO2

beta-(4-Chlorophenyl)gaba

(+-)-Baclofen

DL-Baclofen

DL-4-Amino-3-p-chlorophenylbutanoic acid

baclofene

baclofeno

4-Amino-3-(4-chlorophenyl)butyric acid

beta-(Aminomethyl)-4-chlorobenzenepropanoic acid

beta-(p-Chlorophenyl)-gamma-aminobutyric acid

gamma-Amino-beta-(p-chlorophenyl)butyric acid

baclofen

4-amino-3-(4-chlorophenyl)butanoic acid
ID

http://purl.obolibrary.org/obo/CHEBI_2972
activates

http://purl.obolibrary.org/obo/dinto_2126

http://purl.obolibrary.org/obo/dinto_1459
AHFScode

12:20.12
ATCCode

M03BX01
binds

http://purl.obolibrary.org/obo/dinto_1975

http://purl.obolibrary.org/obo/dinto_2126

http://purl.obolibrary.org/obo/dinto_1459
CASRN

1134-47-0
DBBrand

nu-baclofen

pms-baclofen

lioresal intrathecal

baclon

kemstro

lioresal
DBname

baclofen
Definition

A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000589

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0001505

http://purl.obolibrary.org/obo/OAE_0000888

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001045

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0001744

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0001489

http://purl.obolibrary.org/obo/OAE_0000611

http://purl.obolibrary.org/obo/OAE_0001449

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000482

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000426

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000861

http://purl.obolibrary.org/obo/OAE_0000612

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001340

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000691

http://purl.obolibrary.org/obo/OAE_0000802

http://purl.obolibrary.org/obo/OAE_0000671

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0001068

http://purl.obolibrary.org/obo/OAE_0000587

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000586

http://purl.obolibrary.org/obo/OAE_0000510

http://purl.obolibrary.org/obo/OAE_0000842

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000666

http://purl.obolibrary.org/obo/OAE_0000433

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000438

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000606

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000898

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000185

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0001305

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000592

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001291

http://purl.obolibrary.org/obo/OAE_0000881

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0000513

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target

http://purl.obolibrary.org/obo/dinto_2126

http://purl.obolibrary.org/obo/dinto_1459
has role

http://purl.obolibrary.org/obo/CHEBI_51371

http://purl.obolibrary.org/obo/CHEBI_35488

http://purl.obolibrary.org/obo/CHEBI_51373
InChI

InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey

InChIKey=KPYSYYIEGFHWSV-UHFFFAOYSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_1975
label

baclofen
may interact with

http://purl.obolibrary.org/obo/dinto_DB00427
modulates

http://purl.obolibrary.org/obo/dinto_2126

http://purl.obolibrary.org/obo/dinto_1459
prefixIRI

obo2:CHEBI_2972
prefLabel

baclofen
SMILES

NCC(CC(O)=O)c1ccc(Cl)cc1

NCC(CC(O)=O)C1=CC=C(Cl)C=C1
Synonym

baclofenum

beta-(Aminomethyl)-p-chlorohydrocinnamic acid

C10H12ClNO2

beta-(4-Chlorophenyl)gaba

(+-)-Baclofen

DL-Baclofen

DL-4-Amino-3-p-chlorophenylbutanoic acid

baclofene

baclofeno

4-Amino-3-(4-chlorophenyl)butyric acid

beta-(Aminomethyl)-4-chlorobenzenepropanoic acid

beta-(p-Chlorophenyl)-gamma-aminobutyric acid

gamma-Amino-beta-(p-chlorophenyl)butyric acid

baclofen

4-amino-3-(4-chlorophenyl)butanoic acid
xref

Drugs.com:http://www.drugs.com/baclofen.html

PubChem Compound:2284

Wikipedia:http://en.wikipedia.org/wiki/Baclofen

Beilstein:2104494

ChemSpider:2197

Guide To Pharmacology:1084

Patent:NL6407755

DrugBank:DB00181

Drugs Product Database (DPD):2242151

ChEMBL:132869

ChEBI:2972

BindingDB:24182

KEGG DRUG:D00241

IUPHAR:1084

RxList:http://www.rxlist.com/cgi/generic/baclofen.htm

PharmGKB:PA448533

Wikipedia:Baclofen

CASRN:1134-47-0

Patent:US3471548

National Drug Code Directory:0091-3351-01

PubChem Substance:46508181
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_2972 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2972 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2972 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_2972 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_2972 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_2972 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_2972 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2972 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2972 NIFSTD LOOM
http://purl.bioontology.org/ontology/LNC/LP17857-1 LOINC LOOM
http://purl.obolibrary.org/obo/OMIT_0002794 OMIT LOOM
http://purl.bioontology.org/ontology/NDDF/001677 NDDF LOOM
http://www.drugbank.ca/drugs/DB00181 FTC LOOM
http://purl.bioontology.org/ontology/RCD/j82.. RCD LOOM
http://purl.obolibrary.org/obo/NCIT_C28858 BERO LOOM
http://purl.bioontology.org/ontology/RXNORM/1292 RXNORM LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Baclofen STMSO LOOM
http://www.co-ode.org/ontologies/galen#Baclofen GALEN LOOM
http://purl.bioontology.org/ontology/SNMI/C-68780 SNMI LOOM
http://stirdf.jst.go.jp/id/200907078162111107 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387342009 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.114.500.350.100 RH-MESH LOOM
http://scai.fraunhofer.de/MSOntology#Baclofen MSO LOOM
http://purl.jp/bio/4/id/200906036602827110 IOBC LOOM
http://purl.obolibrary.org/obo/MESH_D001418 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D001418 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001418 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28858 NCIT LOOM
http://stirdf.jst.go.jp/id/200907011971241790 IOBC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Baclofen APAONTO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000560777 PDQ LOOM
https://go.drugbank.com/drugs/DB00181 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0004609 OCHV LOOM
http://www.limics.fr/ontologies/ontoparonmed#Baclofene ONTOPARON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146719 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1663 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/MTHU019852 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4018392 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/M03BX01 ATC LOOM
http://purl.jp/bio/4/id/200906068753530452 IOBC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016315 PMAPP-PMO LOOM