loading...| Preferred Name |
desloratadine |
|
| Synonyms |
descarboethoxyloratadine DESLORATADINE 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine desloratadine 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaene C19H19ClN2 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_291342 |
|
| AHFScode |
04:08.00 |
|
| ATCCode |
R06AX27 |
|
| binds |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 |
|
| blocks | ||
| CASRN |
100643-71-8 |
|
| DBBrand |
claramax clarinex reditabs aerius neoclarityn clarinex |
|
| DBname |
desloratadine |
|
| DBSynonym |
descarboethoxyloratadine desloratidine descarboethoxyoratidine |
|
| Definition |
Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000359 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001077 http://purl.obolibrary.org/obo/OAE_0000462 |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_37955 |
|
| InChI |
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 |
|
| InChIKey |
InChIKey=JAUOIFJMECXRGI-UHFFFAOYSA-N |
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 |
|
| label |
desloratadine |
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB00209 |
|
| modulates | ||
| prefixIRI |
obo2:CHEBI_291342 |
|
| prefLabel |
desloratadine |
|
| SMILES |
Clc1ccc2c(CCc3cccnc3C2=C2CCNCC2)c1 ClC1=CC2=C(C=C1)C(=C1CCNCC1)C1=C(CC2)C=CC=N1 |
|
| Synonym |
descarboethoxyloratadine DESLORATADINE 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine desloratadine 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaene C19H19ClN2 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine |
|
| xref |
Drugs Product Database (DPD):2243919 Wikipedia:http://en.wikipedia.org/wiki/Desloratadine ChemSpider:110575 ChEMBL:15482930 PubChem Substance:46507996 CASRN:100643-71-8 Wikipedia:Desloratadine PharmGKB:PA164776964 Patent:EP208855 ChEMBL:9934454 Beilstein:4263164 DrugBank:DB00967 RxList:http://www.rxlist.com/cgi/generic3/clarinex.htm ChEBI:291342 PubChem Compound:124087 BindingDB:50073179 Drugs.com:http://www.drugs.com/cdi/desloratadine.html National Drug Code Directory:0085-1264-01 Patent:US4659716 ChEMBL:11844681 KEGG DRUG:D03693 |
|
| subClassOf |