The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	rifampicin
Synonyms	Rifampin Rifampicin (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate rifampicina 3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV RFP rifampicin rifampicinum C43H58N4O12 (7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl acetate
ID	http://purl.obolibrary.org/obo/CHEBI_28077
activates	http://purl.obolibrary.org/obo/dinto_3162
AHFScode	08:16.04
altId	CHEBI:45308 CHEBI:26577 CHEBI:8858
ATCCode	J04AB02
CASRN	13292-46-1
DBBrand	rimactan rifaldin rimactin rofact rifadine rifaprodin riforal tubocin rimazid rifagen rimactane rifoldine rifoldin archidyn rifadin
DBname	rifampin
DBSynonym	rifampin rfp rifampicin
Definition	A rifamycin that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000882 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0000801 http://purl.obolibrary.org/obo/OAE_0001333 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000989 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000917 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0001364
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1425 http://purl.obolibrary.org/obo/dinto_2084
has role	http://purl.obolibrary.org/obo/CHEBI_59517 http://purl.obolibrary.org/obo/CHEBI_33231 http://purl.obolibrary.org/obo/CHEBI_37416 http://purl.obolibrary.org/obo/CHEBI_35816
InChI	InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
InChIKey	InChIKey=JQXXHWHPUNPDRT-WLSIYKJHSA-N
induces	http://purl.obolibrary.org/obo/dinto_0588 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1992 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0762 http://purl.obolibrary.org/obo/dinto_0456 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0276 http://purl.obolibrary.org/obo/dinto_0465
inhibits	http://purl.obolibrary.org/obo/dinto_1977 http://purl.obolibrary.org/obo/dinto_1425 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1987 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1322 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_2084
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1221
is transported by	http://purl.obolibrary.org/obo/dinto_1824 http://purl.obolibrary.org/obo/dinto_1440
label	rifampicin
may interact with	http://purl.obolibrary.org/obo/dinto_DB00683 http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_71219 http://purl.obolibrary.org/obo/CHEBI_32250 http://purl.obolibrary.org/obo/CHEBI_66919 http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_3219 http://purl.obolibrary.org/obo/CHEBI_7627 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/dinto_DB00839 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00912 http://purl.obolibrary.org/obo/CHEBI_474180 http://purl.obolibrary.org/obo/CHEBI_49960 http://purl.obolibrary.org/obo/CHEBI_49668 http://purl.obolibrary.org/obo/dinto_DB08864 http://purl.obolibrary.org/obo/CHEBI_71940 http://purl.obolibrary.org/obo/CHEBI_68642 http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/dinto_DB01142 http://purl.obolibrary.org/obo/CHEBI_39867 http://purl.obolibrary.org/obo/CHEBI_68621 http://purl.obolibrary.org/obo/CHEBI_66901 http://purl.obolibrary.org/obo/CHEBI_3650 http://purl.obolibrary.org/obo/CHEBI_37924 http://purl.obolibrary.org/obo/CHEBI_5441 http://purl.obolibrary.org/obo/dinto_DB01384 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_3223 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_499361 http://purl.obolibrary.org/obo/CHEBI_8499 http://purl.obolibrary.org/obo/dinto_DB00344 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/CHEBI_10110 http://purl.obolibrary.org/obo/CHEBI_72690 http://purl.obolibrary.org/obo/dinto_DB00540 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/CHEBI_6541 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/CHEBI_575568 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_17303 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/CHEBI_47499 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/CHEBI_68610 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/dinto_DB01380 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_5613 http://purl.obolibrary.org/obo/CHEBI_63609 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/CHEBI_47780 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/dinto_DB06287 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_3127 http://purl.obolibrary.org/obo/CHEBI_41423 http://purl.obolibrary.org/obo/CHEBI_68595 http://purl.obolibrary.org/obo/CHEBI_40303 http://purl.obolibrary.org/obo/dinto_DB00980 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/dinto_DB01289 http://purl.obolibrary.org/obo/CHEBI_4325 http://purl.obolibrary.org/obo/CHEBI_3558 http://purl.obolibrary.org/obo/CHEBI_17698 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_50845 http://purl.obolibrary.org/obo/dinto_DB01357 http://purl.obolibrary.org/obo/CHEBI_3766 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_47657 http://purl.obolibrary.org/obo/CHEBI_75045 http://purl.obolibrary.org/obo/CHEBI_7565 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_72292 http://purl.obolibrary.org/obo/CHEBI_6367 http://purl.obolibrary.org/obo/dinto_DB06212 http://purl.obolibrary.org/obo/dinto_DB01558 http://purl.obolibrary.org/obo/CHEBI_8764 http://purl.obolibrary.org/obo/CHEBI_32020 http://purl.obolibrary.org/obo/CHEBI_15367 http://purl.obolibrary.org/obo/CHEBI_6916 http://purl.obolibrary.org/obo/CHEBI_63637 http://purl.obolibrary.org/obo/dinto_DB08901 http://purl.obolibrary.org/obo/dinto_DB01067 http://purl.obolibrary.org/obo/dinto_DB00414 http://purl.obolibrary.org/obo/CHEBI_5136 http://purl.obolibrary.org/obo/CHEBI_4728 http://purl.obolibrary.org/obo/CHEBI_49375 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_8466 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/CHEBI_50885 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_6904 http://purl.obolibrary.org/obo/dinto_DB01058 http://purl.obolibrary.org/obo/CHEBI_6807 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/dinto_DB00440 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_73275 http://purl.obolibrary.org/obo/CHEBI_6339 http://purl.obolibrary.org/obo/CHEBI_50122 http://purl.obolibrary.org/obo/dinto_DB08884 http://purl.obolibrary.org/obo/CHEBI_39112 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/CHEBI_9168 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/dinto_DB00977 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/CHEBI_73274 http://purl.obolibrary.org/obo/CHEBI_49575 http://purl.obolibrary.org/obo/CHEBI_31739 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/CHEBI_63584 http://purl.obolibrary.org/obo/dinto_DB01382 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_10102 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_119915 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/CHEBI_27999 http://purl.obolibrary.org/obo/CHEBI_71418 http://purl.obolibrary.org/obo/CHEBI_114785 http://purl.obolibrary.org/obo/CHEBI_4784 http://purl.obolibrary.org/obo/CHEBI_68647 http://purl.obolibrary.org/obo/CHEBI_47781 http://purl.obolibrary.org/obo/CHEBI_9611 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/CHEBI_47381 http://purl.obolibrary.org/obo/CHEBI_9674 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/CHEBI_71272 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/CHEBI_5383 http://purl.obolibrary.org/obo/CHEBI_65349 http://purl.obolibrary.org/obo/CHEBI_2675 http://purl.obolibrary.org/obo/CHEBI_31654 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_45783 http://purl.obolibrary.org/obo/CHEBI_2569 http://purl.obolibrary.org/obo/CHEBI_2666 http://purl.obolibrary.org/obo/CHEBI_6402
prefixIRI	obo2:CHEBI_28077
prefLabel	rifampicin
SMILES	CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\\C=N\\N1CCN(C)CC1)c(O)c4c3C2=O CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C2=O)C2=C(O)C(\C=N\N4CCN(C)CC4)=C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(O)=C2C(O)=C3C
Synonym	Rifampin Rifampicin (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate rifampicina 3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV RFP rifampicin rifampicinum C43H58N4O12 (7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl acetate
xref	Guide To Pharmacology:2765 DrugBank:DB01045 Patent:NL6509961 Reaxys:5723476 PharmGKB:PA451250 PDBeChem:RFP Drugs.com:http://www.drugs.com/cdi/rifampin.html RxList:http://www.rxlist.com/cgi/generic2/rifampin.htm KEGG COMPOUND:C06688 KEGG DRUG:D00211 Drugs Product Database (DPD):393444 CASRN:13292-46-1 Beilstein:5723476 Wikipedia:Rifampicin Patent:US3342810 ChEBI:28077 ChEMBL:465189 National Drug Code Directory:0904-5282-06 IUPHAR:2765 Wikipedia:http://en.wikipedia.org/wiki/Rifampin HMDB:HMDB15179
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_28077	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	PHIPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	GENEPIO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	MCO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_28077	OBA	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	EFO	LOOM
http://www.co-ode.org/ontologies/galen#Rifampicin	GALEN	LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00588	OCIMIDO	LOOM
https://go.drugbank.com/drugs/DB01045	MDM	LOOM
http://purl.jp/bio/10/gmo/GMO_001694	GMO	LOOM
http://purl.bioontology.org/ontology/ATC/J04AB02	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	GENEPIO	LOOM
http://purl.obolibrary.org/obo/CHEBI_28077	MCO	LOOM