The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

tolbutamide
Synonyms

Tolylsulfonylbutylurea

N-n-Butyl-N'-tosylurea

1-Butyl-3-(p-tolylsulfonyl)urea

Tolbutamide

1-Butyl-3-tosylurea

N-Butyl-N'-p-toluenesulfonylurea

C12H18N2O3S

1-Butyl-3-(p-methylphenylsulfonyl)urea

3-(p-Tolyl-4-sulfonyl)-1-butylurea

Orinase (TN)

N-(4-Methylbenzenesulfonyl)-N'-butylurea

N-Butyl-N'-(4-methylphenylsulfonyl)urea

tolbutamidum

N-(p-Methylbenzenesulfonyl)-N'-butylurea

tolbutamida

3-butyl-1-[(4-methylbenzene)sulfonyl]urea

N-Butyl-N'-(p-tolylsulfonyl)urea

1-p-Toluenesulfonyl-3-butylurea

N-(4-Methylphenylsulfonyl)-N'-butylurea

N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide

tolbutamide

N-(Sulfonyl-p-methylbenzene)-N'-N-butylurea
ID

http://purl.obolibrary.org/obo/CHEBI_27999
AHFScode

68:20.20
altId

CHEBI:27019

CHEBI:9616
ATCCode

A10BB03

V04CA01
binds

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_4065

http://purl.obolibrary.org/obo/dinto_2142

http://purl.obolibrary.org/obo/dinto_2004

http://purl.obolibrary.org/obo/dinto_1987

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_3338

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_1959

http://purl.obolibrary.org/obo/dinto_1322
CASRN

64-77-7
DBBrand

oterben

dirastan

diaben

diabuton

tolbutamid

artosin

sk-tolbutamide

tolumid

orinase diagnostic

novo-butamide

diabetol

orinase

drabet

willbutamide

tolylsulfonylbutylurea

ipoglicone

oralin

aglicid

dolipol

orabet

toluvan

toluina

butamid

tolbusal

orezan

diabetamid

tol-tab

pramidex

artozin

glyconon

orinaz

restinon

butamide

diasulfon

arkozal

rastinon

mobenol

apo-tolbutamide
DBname

tolbutamide
Definition

A urea that consists of 1-butylurea having a tosyl group attached at the 3-position.
has pharmacological target

http://purl.obolibrary.org/obo/dinto_2142
has role

http://purl.obolibrary.org/obo/CHEBI_35526

http://purl.obolibrary.org/obo/CHEBI_50509
InChI

InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChIKey

InChIKey=JLRGJRBPOGGCBT-UHFFFAOYSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_4065

http://purl.obolibrary.org/obo/dinto_2142

http://purl.obolibrary.org/obo/dinto_2004

http://purl.obolibrary.org/obo/dinto_1987

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_3338

http://purl.obolibrary.org/obo/dinto_0520
is metabolised by

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_1959

http://purl.obolibrary.org/obo/dinto_1221
is substrate of

http://purl.obolibrary.org/obo/dinto_2058

http://purl.obolibrary.org/obo/dinto_0291

http://purl.obolibrary.org/obo/dinto_1959

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_1322
is transported by

http://purl.obolibrary.org/obo/dinto_1322
label

tolbutamide
may interact with

http://purl.obolibrary.org/obo/CHEBI_31348

http://purl.obolibrary.org/obo/CHEBI_8214

http://purl.obolibrary.org/obo/CHEBI_4551

http://purl.obolibrary.org/obo/CHEBI_119573

http://purl.obolibrary.org/obo/CHEBI_5296

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/CHEBI_45863

http://purl.obolibrary.org/obo/CHEBI_10100

http://purl.obolibrary.org/obo/CHEBI_41774

http://purl.obolibrary.org/obo/dinto_DB00196

http://purl.obolibrary.org/obo/CHEBI_8499

http://purl.obolibrary.org/obo/CHEBI_49662

http://purl.obolibrary.org/obo/CHEBI_6541

http://purl.obolibrary.org/obo/CHEBI_8249

http://purl.obolibrary.org/obo/CHEBI_4856

http://purl.obolibrary.org/obo/CHEBI_9342

http://purl.obolibrary.org/obo/CHEBI_15365

http://purl.obolibrary.org/obo/CHEBI_3750

http://purl.obolibrary.org/obo/dinto_DB00214

http://purl.obolibrary.org/obo/CHEBI_53766

http://purl.obolibrary.org/obo/CHEBI_3127

http://purl.obolibrary.org/obo/CHEBI_41423

http://purl.obolibrary.org/obo/dinto_DB00373

http://purl.obolibrary.org/obo/dinto_DB00731

http://purl.obolibrary.org/obo/CHEBI_4325

http://purl.obolibrary.org/obo/dinto_DB06268

http://purl.obolibrary.org/obo/CHEBI_9332

http://purl.obolibrary.org/obo/CHEBI_17698

http://purl.obolibrary.org/obo/CHEBI_3441

http://purl.obolibrary.org/obo/dinto_DB01357

http://purl.obolibrary.org/obo/CHEBI_5855

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/CHEBI_2904

http://purl.obolibrary.org/obo/CHEBI_60761

http://purl.obolibrary.org/obo/dinto_DB01110

http://purl.obolibrary.org/obo/dinto_DB01067

http://purl.obolibrary.org/obo/CHEBI_5130

http://purl.obolibrary.org/obo/CHEBI_50730

http://purl.obolibrary.org/obo/CHEBI_6904

http://purl.obolibrary.org/obo/dinto_DB00784

http://purl.obolibrary.org/obo/CHEBI_48574

http://purl.obolibrary.org/obo/dinto_DB00440

http://purl.obolibrary.org/obo/dinto_DB00052

http://purl.obolibrary.org/obo/CHEBI_10033

http://purl.obolibrary.org/obo/CHEBI_32315

http://purl.obolibrary.org/obo/CHEBI_2379

http://purl.obolibrary.org/obo/CHEBI_102484

http://purl.obolibrary.org/obo/dinto_DB01580

http://purl.obolibrary.org/obo/CHEBI_7444

http://purl.obolibrary.org/obo/CHEBI_51450

http://purl.obolibrary.org/obo/CHEBI_6121

http://purl.obolibrary.org/obo/dinto_DB01320

http://purl.obolibrary.org/obo/CHEBI_73044

http://purl.obolibrary.org/obo/CHEBI_6343

http://purl.obolibrary.org/obo/dinto_DB01026

http://purl.obolibrary.org/obo/CHEBI_28077

http://purl.obolibrary.org/obo/CHEBI_46345

http://purl.obolibrary.org/obo/CHEBI_9328

http://purl.obolibrary.org/obo/CHEBI_5383

http://purl.obolibrary.org/obo/dinto_DB00622

http://purl.obolibrary.org/obo/CHEBI_5118
prefixIRI

obo2:CHEBI_27999
prefLabel

tolbutamide
SMILES

CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1

CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1
Synonym

Tolylsulfonylbutylurea

N-n-Butyl-N'-tosylurea

1-Butyl-3-(p-tolylsulfonyl)urea

Tolbutamide

1-Butyl-3-tosylurea

N-Butyl-N'-p-toluenesulfonylurea

C12H18N2O3S

1-Butyl-3-(p-methylphenylsulfonyl)urea

3-(p-Tolyl-4-sulfonyl)-1-butylurea

Orinase (TN)

N-(4-Methylbenzenesulfonyl)-N'-butylurea

N-Butyl-N'-(4-methylphenylsulfonyl)urea

tolbutamidum

N-(p-Methylbenzenesulfonyl)-N'-butylurea

tolbutamida

3-butyl-1-[(4-methylbenzene)sulfonyl]urea

N-Butyl-N'-(p-tolylsulfonyl)urea

1-p-Toluenesulfonyl-3-butylurea

N-(4-Methylphenylsulfonyl)-N'-butylurea

N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide

tolbutamide

N-(Sulfonyl-p-methylbenzene)-N'-N-butylurea
xref

CiteXplore:20880646

CiteXplore:21757329

Wikipedia:Tolbutamide

CiteXplore:15207658

CiteXplore:12355256

DrugBank:DB01124

CiteXplore:21535124

KEGG COMPOUND:C07148

CiteXplore:16426753

Patent:US2968158

CiteXplore:21193530

CiteXplore:19059420

CiteXplore:15655519

CiteXplore:15620874

IUPHAR:2415

CiteXplore:16290322

CiteXplore:11840346

CiteXplore:15317941

Patent:DE1066575

CiteXplore:12042355

Patent:GB808071

PubChem Compound:5505

CiteXplore:21831467

Wikipedia:http://en.wikipedia.org/wiki/Tolbutamide

CiteXplore:11835228

PubChem Substance:46508421

CiteXplore:11911494

CiteXplore:21827497

Drugs.com:http://www.drugs.com/cdi/tolbutamide.html

CiteXplore:22028182

Guide To Pharmacology:2415

PharmGKB:PA451718

ChEBI:27999

National Drug Code Directory:0378-0215-01

CiteXplore:22079696

CiteXplore:21178111

Reaxys:1984428

ChEMBL:146726

KEGG DRUG:D00380

Drugs Product Database (DPD):156663

CiteXplore:21471135

CiteXplore:21712613

ChemSpider:5304

NIST Chemistry WebBook:64-77-7

CASRN:64-77-7
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_27999 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 CCONT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 DIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 HINO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_27999 DIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 EFO LOOM
http://purl.bioontology.org/ontology/VANDF/4017888 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/V04CA01 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 DRON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014044 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.828.896 RH-MESH LOOM
https://go.drugbank.com/drugs/DB01124 MDM LOOM
http://purl.jp/bio/4/id/200906064676545934 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP32705-3 LOINC LOOM
http://stirdf.jst.go.jp/id/200907039743469090 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373481003 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66610 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040374 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/2841-5754 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/10635 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Tolbutamide GALEN LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#tolbutamide SDO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU062988 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C66610 BERO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000684270 PDQ LOOM
http://www.drugbank.ca/drugs/DB01124 FTC LOOM
http://purl.bioontology.org/ontology/SNMI/C-A2460 SNMI LOOM
http://purl.obolibrary.org/obo/MESH_D014044 BERO LOOM
http://purl.bioontology.org/ontology/ATC/A10BB03 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0014886 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.795.896 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017441 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12340 OCHV LOOM
http://purl.obolibrary.org/obo/XCO_0000252 XCO LOOM
http://purl.bioontology.org/ontology/RCD/f3a.. RCD LOOM
http://purl.bioontology.org/ontology/NDDF/000908 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LP16296-3 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D014044 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146241 NDFRT LOOM
http://www.semanticweb.org/khaled/ontologies/2024/7/CDMOnto#Tolbutamide CDMONTO LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_27999 NIFSTD LOOM