The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	cefoxitin
Synonyms	(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ceftoxitin 3-[(carbamoyloxy)methyl]-7alpha-methoxy-7beta-[(thiophen-2-yl)acetamido]-3,4-didehydrocepham-4-carboxylic acid cefoxitinum Rephoxitin Cefoxitin cefoxitina (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid cefoxitin CFX (6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid C16H17N3O7S2 cefoxitine Cephoxitin
ID	http://purl.obolibrary.org/obo/CHEBI_209807
AHFScode	08:12.07.12
altId	CHEBI:658070 CHEBI:41436 CHEBI:3500 CHEBI:471714
ATCCode	J01DC01
binds	http://purl.obolibrary.org/obo/dinto_0413 http://purl.obolibrary.org/obo/dinto_3285 http://purl.obolibrary.org/obo/dinto_3289 http://purl.obolibrary.org/obo/dinto_1920 http://purl.obolibrary.org/obo/dinto_0758 http://purl.obolibrary.org/obo/dinto_1849 http://purl.obolibrary.org/obo/dinto_3095 http://purl.obolibrary.org/obo/dinto_2744 http://purl.obolibrary.org/obo/dinto_0081 http://purl.obolibrary.org/obo/dinto_3995 http://purl.obolibrary.org/obo/dinto_2925 http://purl.obolibrary.org/obo/dinto_1947 http://purl.obolibrary.org/obo/dinto_3472
CASRN	35607-66-0
DBBrand	mefoxin mefoxitin
DBname	cefoxitin
Definition	A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side groups. It is resistant to beta-lactamase.
has effect	http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001333 http://purl.obolibrary.org/obo/OAE_0001707 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000752 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0001434 http://purl.obolibrary.org/obo/OAE_0000405 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001366 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0413 http://purl.obolibrary.org/obo/dinto_3285 http://purl.obolibrary.org/obo/dinto_3289 http://purl.obolibrary.org/obo/dinto_1920 http://purl.obolibrary.org/obo/dinto_0758 http://purl.obolibrary.org/obo/dinto_1849 http://purl.obolibrary.org/obo/dinto_3095 http://purl.obolibrary.org/obo/dinto_2744 http://purl.obolibrary.org/obo/dinto_0081 http://purl.obolibrary.org/obo/dinto_3995 http://purl.obolibrary.org/obo/dinto_2925 http://purl.obolibrary.org/obo/dinto_1947
has role	http://purl.obolibrary.org/obo/CHEBI_36047
InChI	InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1
InChIKey	InChIKey=WZOZEZRFJCJXNZ-ZBFHGGJFSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0413 http://purl.obolibrary.org/obo/dinto_3285 http://purl.obolibrary.org/obo/dinto_3289 http://purl.obolibrary.org/obo/dinto_1920 http://purl.obolibrary.org/obo/dinto_0758 http://purl.obolibrary.org/obo/dinto_1849 http://purl.obolibrary.org/obo/dinto_3095 http://purl.obolibrary.org/obo/dinto_2744 http://purl.obolibrary.org/obo/dinto_0081 http://purl.obolibrary.org/obo/dinto_3995 http://purl.obolibrary.org/obo/dinto_2925 http://purl.obolibrary.org/obo/dinto_1947
is metabolised by	http://purl.obolibrary.org/obo/dinto_3472
is substrate of	http://purl.obolibrary.org/obo/dinto_3472
label	cefoxitin
may interact with	http://purl.obolibrary.org/obo/dinto_DB00994 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/dinto_DB01172 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB00798 http://purl.obolibrary.org/obo/CHEBI_17076 http://purl.obolibrary.org/obo/dinto_DB00955 http://purl.obolibrary.org/obo/dinto_DB00684 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_2637 http://purl.obolibrary.org/obo/CHEBI_8426
prefixIRI	obo2:CHEBI_209807
prefLabel	cefoxitin
SMILES	[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)CC1=CC=CS1)OC)C(O)=O [H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)Cc1cccs1)OC)C(O)=O
Synonym	(6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ceftoxitin 3-[(carbamoyloxy)methyl]-7alpha-methoxy-7beta-[(thiophen-2-yl)acetamido]-3,4-didehydrocepham-4-carboxylic acid cefoxitinum Rephoxitin Cefoxitin cefoxitina (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid cefoxitin CFX (6R,7S)-4-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-enyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid C16H17N3O7S2 cefoxitine Cephoxitin
xref	KEGG COMPOUND:C06887 ChEMBL:17220412 DrugBank:DB01331 KEGG DRUG:D02345 RxList:http://www.rxlist.com/cgi/generic/cefoxitin.htm Patent:DE2129675 CASRN:35607-66-0 ChEMBL:18056283 PharmGKB:PA448856 National Drug Code Directory:0143-9878-25 Drugs.com:http://www.drugs.com/cdi/cefoxitin.html Wikipedia:Cefoxitin ChEMBL:18070972 Patent:DE2203653 ChemSpider:389981 PubChem Compound:441199 PubChem Substance:46505845 ChEMBL:17353248 Reaxys:4216947 Patent:US4297488 Drugs Product Database (DPD):2128187 CiteXplore:12569987 ChEMBL:17043131 ChEMBL:17178800 ChEMBL:17923492 Wikipedia:http://en.wikipedia.org/wiki/Cefoxitin Beilstein:4216947 CiteXplore:2083978 ChEBI:209807 ChEMBL:17387156 ChEMBL:8360877 PDBeChem:CFX
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_209807	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	UPHENO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	PHIPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_209807	GENEPIO	SAME_URI
http://purl.obolibrary.org/obo/ARO_0000008	ARO	LOOM
http://stirdf.jst.go.jp/id/200907075095089330	IOBC	LOOM
https://go.drugbank.com/drugs/DB01331	MDM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61665	NCIT	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU068952	LOINC	LOOM
http://purl.bioontology.org/ontology/LNC/LP15205-5	LOINC	LOOM
http://purl.jp/bio/4/id/200906057898912530	IOBC	LOOM
http://www.co-ode.org/ontologies/galen#Cefoxitin	GALEN	LOOM
http://purl.bioontology.org/ontology/RXNORM/2189	RXNORM	LOOM
http://purl.obolibrary.org/obo/OMIT_0003770	OMIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4019665	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/J01DC01	ATC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002440	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060440	LOINC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372780005	SNOMEDCT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015903	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RCD/e64..	RCD	LOOM
http://purl.bioontology.org/ontology/SNMI/C-53740	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.250.222	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_209807	GENEPIO	LOOM
http://purl.obolibrary.org/obo/MESH_D002440	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147757	NDFRT	LOOM
http://purl.bioontology.org/ontology/NDDF/004843	NDDF	LOOM
http://purl.jp/bio/10/gmo/GMO_002060	GMO	LOOM
http://purl.bioontology.org/ontology/MESH/D002440	MESH	LOOM
http://purl.obolibrary.org/obo/ARO_0000008	ARO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.250.222	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.250.222	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C61665	BERO	LOOM