loading...| Preferred Name | alpha 1 antitrypsin | |
| Synonyms |
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| ID |
http://scai.fraunhofer.de/CSEO#CSEO_00000852 |
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| isDefinedBy |
Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily. inflammation-inducible serine protease inhibitor synthesized primarily in liver, then secreted into blood where it accounts for the bulk of blood protease inhibitor activity; is an important regulator of neutrophil elastase. |
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| label |
alpha 1 antitrypsin |
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| prefixIRI |
CSEO_00000852 |
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| prefLabel |
alpha 1 antitrypsin |
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| Reference |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Alpha_1_Antitrypsin |
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| source |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Alpha_1_Antitrypsin http://purl.bioontology.org/ontology/CSP/1040-6544 |
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| Synonym |
AAT Alpha-1 Antitrypsin |
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| subClassOf |