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COVID-19 Ontology
Last uploaded:
February 25, 2021
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| Preferred Name | fosamprenavir | |
| Synonyms |
fosamprenavir FOS-APV (3S)-tetrahydrofuran-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-phenyl-3-(phosphonooxy)butan-2-yl]carbamate |
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| Definitions |
A sulfonamide with a structure based on that of sulfanilamide substituted on the sulfonamide nitrogen by a (2R,3S)-4-phenyl-2-(phosphonooxy)-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butyl group. It is a pro-drug of the HIV protease inhibitor and antiretroviral drug amprenavir. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_82941 |
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| alternative_term |
(3S)-tetrahydrofuran-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-phenyl-3-(phosphonooxy)butan-2-yl]carbamate
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| charge |
0
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| database_cross_reference |
PMID:22100576 PMID:25155604 PMID:24929949 KEGG:D02497 CAS:226700-79-4 HMDB:HMDB0015416 PMID:25017682 PMID:23314414 PMID:24741696 Reaxys:9824450 DrugBank:DB01319 Drug_Central:1240 PMID:16890834 PMID:23811744 Wikipedia:Fosamprenavir
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| definition |
A sulfonamide with a structure based on that of sulfanilamide substituted on the sulfonamide nitrogen by a (2R,3S)-4-phenyl-2-(phosphonooxy)-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butyl group. It is a pro-drug of the HIV protease inhibitor and antiretroviral drug amprenavir.
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| formula |
C25H36N3O9PS
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| fromPubMed |
true
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
fosamprenavir FOS-APV
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|
| id |
CHEBI:82941
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| imported from | ||
| in_subset | ||
| inchi |
InChI=1S/C25H36N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1
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| inchikey |
MLBVMOWEQCZNCC-OEMFJLHTSA-N
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|
| label |
fosamprenavir
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|
| mass |
585.60700
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|
| monoisotopicmass |
585.19099
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| notation |
CHEBI:82941
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| oboInOwl:hasDbXRef | ||
| preferred label |
fosamprenavir
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| prefLabel |
fosamprenavir
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| smiles |
CC(C)CN(C[C@@H](OP(O)(O)=O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1
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| textual definition |
A sulfonamide with a structure based on that of sulfanilamide substituted on the sulfonamide nitrogen by a (2R,3S)-4-phenyl-2-(phosphonooxy)-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butyl group. It is a pro-drug of the HIV protease inhibitor and antiretroviral drug amprenavir.
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| subClassOf |
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