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Chemical Entities of Biological Interest Ontology
| Preferred Name | paromomycin | |
| Synonyms |
R-400 Zygomycin A1 paromomycinum R 400 paucimycinum estomycin crestomycin (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside Monomycin A paucimycin Neomycin E Catenulin paromomicina paromomycin hydroxymycin paromomycine Paromomycin I Aminosidin neomycin E Hydroxymycin aminosidine PAROMOMYCIN Paromomycin |
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| Definitions |
An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_7934 |
|
| charge |
0
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| database_cross_reference |
Patent:US2895876 KEGG:D07467 PMID:8036682 Drug_Central:2067 CAS:7542-37-2 PMID:18447603 KEGG:C00832 PDBeChem:PAR Reaxys:72285 DrugBank:DB01421 Patent:US2916485 PMID:18947845
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|
| definition |
An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.
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| formula |
C23H45N5O14
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| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35820 http://purl.obolibrary.org/obo/CHEBI_36047 |
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| has_alternative_id |
CHEBI:44703
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| has_exact_synonym |
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside PAROMOMYCIN Paromomycin
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
R-400 Zygomycin A1 paromomycinum R 400 paucimycinum estomycin crestomycin (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside Monomycin A paucimycin Neomycin E Catenulin paromomicina paromomycin hydroxymycin paromomycine Paromomycin I Aminosidin neomycin E Hydroxymycin aminosidine
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|
| id |
CHEBI:7934
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| in_subset | ||
| inchi |
InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
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| inchikey |
UOZODPSAJZTQNH-LSWIJEOBSA-N
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|
| label |
paromomycin
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|
| mass |
615.62850
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|
| monoisotopicmass |
615.29630
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| notation |
CHEBI:7934
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| prefLabel |
paromomycin
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| smiles |
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
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| treeView | ||
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