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Chemical Entities of Biological Interest Ontology
| Preferred Name | oxyphenbutazone | |
| Synonyms |
1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione oxyphenbutazonum 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene Oxyphenylbutazone Oxi-fenibutol p-Oxyphenylbutazone Hydroxyphenylbutazon Oxifenylbutazon 4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine Oxiphenbutazonum p-Hydroxyphenylbutazone 4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione oxyphenbutazone 4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine oxifenbutazona 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione |
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| Definitions |
A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_76258 |
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| charge |
0
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| database_cross_reference |
PMID:7001487 Patent:WO2005107748 PMID:766157 PMID:546857 PMID:7368966 PMID:6860567 PMID:21428758 PMID:6617711 Patent:EP642336 Reaxys:307474 Patent:US2008014272 PMID:1222682 PMID:14345781 Wikipedia:Oxyphenbutazone PMID:7309664 PMID:19161668 PMID:6894379 PMID:380595 PMID:501546 DrugBank:DB03585 PMID:20299217 KEGG:C19494 CAS:129-20-4 LINCS:LSM-5029 KEGG:D08324 Drug_Central:2036 PMID:835859 PMID:23012453 PMID:2862290 PMID:23983013 PMID:18963985 PMID:141661
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|
| definition |
A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.
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| formula |
C19H20N2O3
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| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_35493 http://purl.obolibrary.org/obo/CHEBI_35845 http://purl.obolibrary.org/obo/CHEBI_49103 http://purl.obolibrary.org/obo/CHEBI_76206 http://purl.obolibrary.org/obo/CHEBI_33281 |
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione oxyphenbutazonum 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine 3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene Oxyphenylbutazone Oxi-fenibutol p-Oxyphenylbutazone Hydroxyphenylbutazon Oxifenylbutazon 4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione 1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine Oxiphenbutazonum p-Hydroxyphenylbutazone 4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione oxyphenbutazone 4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine oxifenbutazona 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
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|
| id |
CHEBI:76258
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| in_subset | ||
| inchi |
InChI=1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3
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| inchikey |
HFHZKZSRXITVMK-UHFFFAOYSA-N
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| label |
oxyphenbutazone
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|
| mass |
324.37370
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| monoisotopicmass |
324.14739
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| notation |
CHEBI:76258
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| prefLabel |
oxyphenbutazone
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| smiles |
CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1
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| treeView | ||
| subClassOf |
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