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Chemical Entities of Biological Interest Ontology
| Preferred Name | teniposide | |
| Synonyms |
VM26 HSDB 6546 teniposide teniposidum 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside VM-26 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) NSC 122819 teniposido NSC-122819 Vumon (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside |
|
| Definitions |
A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_75988 |
|
| charge |
0
|
|
| database_cross_reference |
DrugBank:DB00444 PMID:26253377 PMID:11516526 MetaCyc:CPD-16755 PMID:22771706 HMDB:HMDB0014587 PMID:21430063 PMID:22846410 Drug_Central:2590 PMID:23679827 PMID:25151861 PMID:32194707 PMID:23838380 Wikipedia:Teniposide Reaxys:1417328 PMID:1411643 PMID:32015321 PMID:30409428 PMID:1063066 PMID:23466610 PDBeChem:9TP PMID:25899285 PMID:21821840 PMID:1411642 PMID:25448575 PMID:22644709 KEGG:C11153 PMID:1329226 CAS:29767-20-2 KEGG:D02698 PMID:24969912 PMID:27596115 PMID:23266449
|
|
| definition |
A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.
|
|
| formula |
C32H32O13S
|
|
| has functional parent | ||
| has role | ||
| has_alternative_id |
CHEBI:9917
|
|
| has_exact_synonym |
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
VM26 HSDB 6546 teniposide teniposidum 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside VM-26 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) NSC 122819 teniposido NSC-122819 Vumon
|
|
| id |
CHEBI:75988
|
|
| in_subset | ||
| inchi |
InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1
|
|
| inchikey |
NRUKOCRGYNPUPR-QBPJDGROSA-N
|
|
| label |
teniposide
|
|
| mass |
656.660
|
|
| monoisotopicmass |
656.15636
|
|
| notation |
CHEBI:75988
|
|
| prefLabel |
teniposide
|
|
| smiles |
[H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=C(C=C3OCOC3=C1)[C@H]2O[C@@H]1O[C@]2([H])CO[C@]([H])(O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1
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|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_35618 http://purl.obolibrary.org/obo/CHEBI_59770 http://purl.obolibrary.org/obo/CHEBI_26961 http://purl.obolibrary.org/obo/CHEBI_33853 http://purl.obolibrary.org/obo/CHEBI_63367 http://purl.obolibrary.org/obo/CHEBI_37581 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35618 http://purl.obolibrary.org/obo/CHEBI_59770 http://purl.obolibrary.org/obo/CHEBI_26961 http://purl.obolibrary.org/obo/CHEBI_33853 http://purl.obolibrary.org/obo/CHEBI_63367 http://purl.obolibrary.org/obo/CHEBI_37581 |
| Delete | Subject | Author | Type | Created |
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