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Chemical Entities of Biological Interest Ontology
| Preferred Name | lomitapide | |
| Synonyms |
lomitapida lomitapide lomitapidum BMS 201038 AEGR 773 BMS201038 AEGR-773 Lojuxta BMS-201038 AEGR773 AEGR733 AEGR 733 Juxtapid AEGR-733 N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide |
|
| Definitions |
A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_72297 |
|
| charge |
0
|
|
| database_cross_reference |
PMID:23147576 PMID:28154305 PMID:25702706 Patent:US2012035204 Patent:US2010273829 KEGG:D09637 PMID:20127562 Reaxys:13754976 PMID:28432645 PMID:28255870 PMID:27055957 PMID:21846156 PMID:27232459 PMID:22963620 PMID:28716835 Patent:US2008161279 Patent:US2003162788 PMID:26120010 DrugBank:DB08827 Wikipedia:Lomitapide PMID:28239069 CAS:182431-12-5 PMID:25257075 PMID:23122768 PMID:23122767 Patent:US2011288064 PMID:28598687 Patent:US2012071458 PMID:26686567 Drug_Central:4721 Patent:US2011288110 PMID:17215532 PMID:27785928 PMID:24366202
|
|
| definition |
A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.
|
|
| formula |
C39H37F6N3O2
|
|
| has role | ||
| has_exact_synonym |
N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
lomitapida lomitapide lomitapidum BMS 201038 AEGR 773 BMS201038 AEGR-773 Lojuxta BMS-201038 AEGR773 AEGR733 AEGR 733 Juxtapid AEGR-733
|
|
| id |
CHEBI:72297
|
|
| in_subset | ||
| inchi |
InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
|
|
| inchikey |
MBBCVAKAJPKAKM-UHFFFAOYSA-N
|
|
| is conjugate base of | ||
| label |
lomitapide
|
|
| mass |
693.722
|
|
| monoisotopicmass |
693.27900
|
|
| notation |
CHEBI:72297
|
|
| prefLabel |
lomitapide
|
|
| smiles |
C1(C(NCC(F)(F)F)=O)(CCCCN2CCC(CC2)NC(C3=C(C=CC=C3)C4=CC=C(C=C4)C(F)(F)F)=O)C=5C=CC=CC5C6=C1C=CC=C6
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|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_22702 http://purl.obolibrary.org/obo/CHEBI_83565 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_22702 http://purl.obolibrary.org/obo/CHEBI_83565 |
| Delete | Subject | Author | Type | Created |
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