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Chemical Entities of Biological Interest Ontology
| Preferred Name | procarbazine | |
| Synonyms |
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide Procarbazin N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide procarbazine procarbazina procarbazinum 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide |
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| Definitions |
A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_71417 |
|
| charge |
0
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|
| database_cross_reference |
Patent:US3830840 PMID:22913972 CAS:671-16-9 Patent:US3520926 PMID:22423248 PMID:21420247 Patent:US2008107661 PMID:22851558 PMID:21740300 PMID:23071237 PMID:22708037 Patent:US2007122414 PMID:21870118 KEGG:C07402 PMID:21703849 LINCS:LSM-2272 Drug_Central:2272 HMDB:HMDB0015299 KEGG:D08423 Wikipedia:Procarbazine DrugBank:DB01168 PMID:22744756 Patent:BE618638 Reaxys:958270
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|
| definition |
A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
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|
| formula |
C12H19N3O
|
|
| has role | ||
| has_alternative_id |
CHEBI:8432
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|
| has_exact_synonym |
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide
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|
| has_obo_namespace |
chebi_ontology
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|
| has_related_synonym |
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide Procarbazin N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide procarbazine procarbazina procarbazinum 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine
|
|
| id |
CHEBI:71417
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|
| in_subset | ||
| inchi |
InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16)
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|
| inchikey |
CPTBDICYNRMXFX-UHFFFAOYSA-N
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|
| is conjugate base of | ||
| label |
procarbazine
|
|
| mass |
221.29880
|
|
| monoisotopicmass |
221.15281
|
|
| notation |
CHEBI:71417
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|
| prefLabel |
procarbazine
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|
| smiles |
CNNCc1ccc(cc1)C(=O)NC(C)C
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| treeView | ||
| subClassOf |
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