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Chemical Entities of Biological Interest Ontology
Last uploaded:
January 1, 2025
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| Preferred Name | omacetaxine mepesuccinate | |
| Synonyms |
mepesuccinate d'omacetaxine CGX-635 (-)-homoharringtonine Homoharringtonine omacetaxine mepesuccinate omacetaxini mepesuccinas mepesuccinato de omacetaxina Synribo (2'R,3S,4S,5R)-(-)-homoharringtonine |
|
| Definitions |
A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_71019 |
|
| charge |
0
|
|
| database_cross_reference |
PMID:21468038 PMID:22289991 PMID:23059828 PMID:21294709 PMID:22075327 PMID:21418889 PMID:23086639 Patent:WO2007089878 PMID:23456623 CAS:26833-87-4 PMID:21152934 PMID:22580751 PMID:22896000 PDBeChem:HMT PMID:21845438 PMID:22391162 PMID:22054289 LINCS:LSM-3716 PMID:22714632 Wikipedia:Omacetaxine_mepesuccinate PMID:20971952 Patent:US2010240887 Reaxys:5687925 PMID:21509439 PMID:23053254 Drug_Central:4677 PMID:21916787 PMID:22967374 PMID:21415308 KEGG:D08956 PMID:23109844 PMID:22040954 PMID:22898909 PMID:21258877 PMID:22917222
|
|
| definition |
A cephalotaxine-derived alkaloid ester obtained from Cephalotaxus harringtonia; used for the treatment of chronic or accelerated phase chronic myeloid leukaemia.
|
|
| formula |
C29H39NO9
|
|
| has functional parent | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_149553 |
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
mepesuccinate d'omacetaxine CGX-635 (-)-homoharringtonine Homoharringtonine omacetaxine mepesuccinate omacetaxini mepesuccinas mepesuccinato de omacetaxina Synribo (2'R,3S,4S,5R)-(-)-homoharringtonine
|
|
| id |
CHEBI:71019
|
|
| in_subset | ||
| inchi |
InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
|
|
| inchikey |
HYFHYPWGAURHIV-JFIAXGOJSA-N
|
|
| label |
omacetaxine mepesuccinate
|
|
| mass |
545.62130
|
|
| monoisotopicmass |
545.26248
|
|
| notation |
CHEBI:71019
|
|
| prefLabel |
omacetaxine mepesuccinate
|
|
| smiles |
[H][C@@]12[C@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)C(OC)=C[C@@]11CCCN1CCc1cc3OCOc3cc21
|
|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_47985 http://purl.obolibrary.org/obo/CHEBI_38164 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_47985 http://purl.obolibrary.org/obo/CHEBI_38164 |
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