loading...| Preferred Name | doxapram | |
| Synonyms |
(+-)-doxapram 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone doxapram Doxapram 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one |
|
| Definitions |
A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_681848 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:25819170 VSDB:1819 KEGG:D07873 PMID:527638 Patent:BE613734 DrugBank:DB00561 PMID:4126096 Patent:US3192206 CAS:309-29-5 Drug_Central:953 Wikipedia:Doxapram PMID:4122029 PMID:20140700 LINCS:LSM-5058 Reaxys:628691 PMID:19663568 PMID:26896538 |
|
| definition |
A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering. |
|
| formula |
C24H30N2O2 |
|
| has role | ||
| has_exact_synonym |
Doxapram 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
(+-)-doxapram 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone doxapram |
|
| id |
CHEBI:681848 |
|
| in_subset | ||
| inchi |
InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3 |
|
| inchikey |
XFDJYSQDBULQSI-UHFFFAOYSA-N |
|
| label |
doxapram |
|
| mass |
378.50720 |
|
| monoisotopicmass |
378.23073 |
|
| notation |
CHEBI:681848 |
|
| prefLabel |
doxapram |
|
| smiles |
CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1 |
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| treeView | ||
| subClassOf |