loading...| Preferred Name |
ritanserin |
|
| Synonyms |
6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one ritanserine R 55,667 ritanserin ritanserinum 6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one ritanserina R-55667 |
|
| Definitions |
A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_64195 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:8974378 Wikipedia:Ritanserin PMID:20825390 PMID:12905101 KEGG:D05738 Reaxys:4913835 Patent:US4533665 PMID:18801405 PMID:11897543 CAS:87051-43-2 LINCS:LSM-2906 |
|
| definition |
A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action. |
|
| formula |
C27H25F2N3OS |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35474 http://purl.obolibrary.org/obo/CHEBI_76779 http://purl.obolibrary.org/obo/CHEBI_48561 http://purl.obolibrary.org/obo/CHEBI_48279 |
|
| has_exact_synonym |
6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
ritanserine R 55,667 ritanserin ritanserinum 6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one ritanserina R-55667 |
|
| id |
CHEBI:64195 |
|
| in_subset | ||
| inchi |
InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3 |
|
| inchikey |
JUQLTPCYUFPYKE-UHFFFAOYSA-N |
|
| label |
ritanserin |
|
| mass |
477.56900 |
|
| monoisotopicmass |
477.16864 |
|
| notation |
CHEBI:64195 |
|
| prefLabel |
ritanserin |
|
| smiles |
Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1 |
|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_37143 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_37143 |