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Chemical Entities of Biological Interest Ontology
| Preferred Name | felodipine | |
| Synonyms |
felodipina felodipinum (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate felodipine 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester FELODIPINE ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
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| Definitions |
The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_585948 |
|
| charge |
0
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|
| database_cross_reference |
Patent:US4264611 Reaxys:4331472 Patent:EP7293 KEGG:D00319 CAS:72509-76-3 LINCS:LSM-1447 Wikipedia:Felodipine DrugBank:DB01023 PDBeChem:225 PMID:18457386 Drug_Central:1142
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|
| definition |
The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
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|
| formula |
C18H19Cl2NO4
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|
| has role |
http://purl.obolibrary.org/obo/CHEBI_38070 http://purl.obolibrary.org/obo/CHEBI_35620 |
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| has_alternative_id |
CHEBI:4996 CHEBI:49383
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| has_exact_synonym |
FELODIPINE ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
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|
| has_obo_namespace |
chebi_ontology
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|
| has_related_synonym |
felodipina felodipinum (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate felodipine 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
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|
| id |
CHEBI:585948
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| in_subset | ||
| inchi |
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
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|
| inchikey |
RZTAMFZIAATZDJ-UHFFFAOYSA-N
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|
| label |
felodipine
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|
| mass |
384.25400
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|
| monoisotopicmass |
383.06911
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|
| notation |
CHEBI:585948
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|
| prefLabel |
felodipine
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|
| smiles |
CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC
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|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_50075 http://purl.obolibrary.org/obo/CHEBI_23697 |
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| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50075 http://purl.obolibrary.org/obo/CHEBI_23697 |
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