Chemical Entities of Biological Interest Ontology

Last uploaded: January 1, 2025
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Id http://purl.obolibrary.org/obo/CHEBI_4909
http://purl.obolibrary.org/obo/CHEBI_4909
Preferred Name

etodolac
Definitions
A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
Synonyms
ETODOLIC ACID
1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid
1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
etodolaco
(1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
etodolacum
1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
(+-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
etodolac
(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
ETODOLAC
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Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
label
etodolac
prefLabel
etodolac
database_cross_reference
Wikipedia:Etodolac
Patent:DE2301525
PMID:28166217
PMID:2970548
Patent:US3939178
KEGG:D00315
HMDB:HMDB0014887
CAS:41340-25-4
DrugBank:DB00749
Drug_Central:1103
PMID:2527995
PMID:15369391
LINCS:LSM-1781
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notation
CHEBI:4909
in_subset
inchi
InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)
has_related_synonym
ETODOLIC ACID
1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid
1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
etodolaco
(1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
etodolacum
1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
(+-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
etodolac
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id
CHEBI:4909
charge
0
has_obo_namespace
chebi_ontology
formula
C17H21NO3
subClassOf
inchikey
NNYBQONXHNTVIJ-UHFFFAOYSA-N
mass
287.35350
monoisotopicmass
287.15214
has_alternative_id
CHEBI:126431
type
smiles
CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12
has role
has_exact_synonym
(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
ETODOLAC
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