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Chemical Entities of Biological Interest Ontology
| Preferred Name | diazoxide | |
| Synonyms |
diazoxidum Diazossido diazoxide diazoxido Eudemine Diazoxide 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide |
|
| Definitions |
A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_4495 |
|
| charge |
0
|
|
| database_cross_reference |
KEGG:C06949 PMID:21538163 PMID:15319354 PMID:11014217 PMID:12039709 PMID:21693179 KEGG:D00294 CAS:364-98-7 Patent:DE723278 PMID:18191077 DrugBank:DB01119 Reaxys:523907 PMID:22047130 LINCS:LSM-3639 Patent:US2986573 PMID:20828743 HMDB:HMDB0015251 PMID:20950601 Patent:US3345365 PMID:16777075 Wikipedia:Diazoxide Drug_Central:854 PMID:29438107 PMID:16740260
|
|
| definition |
A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
|
|
| formula |
C8H7ClN2O2S
|
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35498 http://purl.obolibrary.org/obo/CHEBI_35524 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_35522 http://purl.obolibrary.org/obo/CHEBI_64338 http://purl.obolibrary.org/obo/CHEBI_38633 http://purl.obolibrary.org/obo/CHEBI_35674 |
|
| has_alternative_id |
CHEBI:6046
|
|
| has_exact_synonym |
Diazoxide 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
diazoxidum Diazossido diazoxide diazoxido Eudemine
|
|
| id |
CHEBI:4495
|
|
| in_subset | ||
| inchi |
InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
|
|
| inchikey |
GDLBFKVLRPITMI-UHFFFAOYSA-N
|
|
| label |
diazoxide
|
|
| mass |
230.67100
|
|
| monoisotopicmass |
229.99168
|
|
| notation |
CHEBI:4495
|
|
| prefLabel |
diazoxide
|
|
| smiles |
CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
|
|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_35850 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35850 |
| Delete | Subject | Author | Type | Created |
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| No notes to display |