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Chemical Entities of Biological Interest Ontology
| Preferred Name | tolvaptan | |
| Synonyms |
Jynarque tolvaptan RS-tolvaptan Jinarc OPC-41061 Samsca OPC 41061 (+-)-tolvaptan N-(4-{[(5RS)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide (+-)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide (RS)-tolvaptan tolvaptanum rac-N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide |
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| Definitions |
A racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_32246 |
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| charge |
0
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| database_cross_reference |
PMID:34070416 PMID:38097698 PMID:34554640 PMID:38562967 PMID:38509003 PMID:34514204 PMID:38344178 PMID:38652561 PMID:37845144 PMID:38608748 PMID:34386666 PMID:38288467 PMID:38577748 KEGG:D01213 Wikipedia:Tolvaptan PMID:33078835 PMID:12742979 PMID:37982946 PMID:38606040 PMID:38616432 PMID:38423003 PMID:37916285 PMID:38337413 PMID:16211205 PMID:38512373 PMID:38494546 DrugBank:DB06212 PMID:37214762 PMID:38468548 PMID:34476570 PMID:37516894 PMID:38396765 PMID:37466863 PMID:37845430 PMID:38717378 PMID:38414126 Drug_Central:4110 PMID:38710808 CAS:150683-30-0 PMID:37587049 PMID:34526469
|
|
| definition |
A racemate comprising of equimolar amounts of (R)- and (S)-tolvaptan. It is a selective vasopressin V2 receptor antagonist used to treat euvolemic and hypervolemic hyponatremia. It is also used in the treatment of rapidly progressing autosomal dominant polycystic kidney disease to slow the rate of cyst development and renal insufficiency.
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| formula |
C26H25ClN2O3
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| has part | ||
| has role | ||
| has_exact_synonym |
rac-N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
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| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
Jynarque tolvaptan RS-tolvaptan Jinarc OPC-41061 Samsca OPC 41061 (+-)-tolvaptan N-(4-{[(5RS)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide (+-)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide (RS)-tolvaptan tolvaptanum
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|
| id |
CHEBI:32246
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| in_subset | ||
| label |
tolvaptan
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|
| mass |
448.950
|
|
| monoisotopicmass |
448.15537
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|
| notation |
CHEBI:32246
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| prefLabel |
tolvaptan
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| treeView | ||
| subClassOf |
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