loading...| Preferred Name | chronic myelogenous leukemia | |
| Synonyms |
leukemia, chronic myelogenous leukemia, chronic myeloid, atypical leukemia, chronic myeloid chronic myelogenous leukemia chronic myelogenous leukemias leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation chronic myelogenous leukemia, BCR-ABL1 positive chronic myelocytic leukaemia chronic myeloid leukemia CML - chronic myelogenous leukaemia BCR-ABL Positive chronic myelogenous leukaemia chronic myelogenous leukemia, BCR-ABL1 Positive chronic myelogenous leukemia (CML) CML - chronic myelogenous leukemia chronic granulocytic leukemia chronic myelocytic leukemia chronic myelogenous leukaemia BCR-ABL Positive chronic myelogenous leukemia leukemia, chronic myeloid, Philadelphia chromosome positive, somatic chronic granulocytic leukaemia hematopoeitic - chronic myelocytic leukaemia (CML) hematopoeitic - chronic myelocytic leukemia (CML) chronic myelogenous leukaemia (CML) myeloid leukemia, chronic chronic myeloid leukaemia CML |
|
| Definitions |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival. |
|
| ID |
http://www.ebi.ac.uk/efo/EFO_0000339 |
|
| closeMatch |
http://identifiers.org/snomedct/92818009 http://identifiers.org/snomedct/92817004 http://identifiers.org/mesh/D015466 http://identifiers.org/mesh/D015464 http://identifiers.org/snomedct/63364005 http://linkedlifedata.com/resource/umls/id/C1292772 |
|
| database_cross_reference |
Orphanet:521 EFO:0000339 MONDO:0011996 ICDO:9875/3 MedDRA:10009013 DOID:0081088 ICD10:C92.1 GARD:0006105 MEDGEN:75993 ICDO:9863/3 ONCOTREE:CML UMLS:C0023473 UMLS:C0279543 NANDO:2200013 COHD:134603 OMIM:608232 DOID:8552 GARD:6105 ICD9:205.1 KEGG:05220 NCIT:C3174 NCIT:C3177 |
|
| definition |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival. |
|
| exactMatch |
http://identifiers.org/meddra/10009013 http://linkedlifedata.com/resource/umls/id/C0023473 http://purl.obolibrary.org/obo/DOID_8552 |
|
| gwas_trait |
true |
|
| has modifier | ||
| has_exact_synonym |
chronic myelogenous leukemia chronic myelogenous leukemias leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation chronic myelogenous leukemia, BCR-ABL1 positive chronic myelocytic leukaemia chronic myeloid leukemia CML - chronic myelogenous leukaemia BCR-ABL Positive chronic myelogenous leukaemia chronic myelogenous leukemia, BCR-ABL1 Positive chronic myelogenous leukemia (CML) CML - chronic myelogenous leukemia chronic granulocytic leukemia chronic myelocytic leukemia chronic myelogenous leukaemia BCR-ABL Positive chronic myelogenous leukemia leukemia, chronic myeloid, Philadelphia chromosome positive, somatic chronic granulocytic leukaemia hematopoeitic - chronic myelocytic leukaemia (CML) hematopoeitic - chronic myelocytic leukemia (CML) chronic myelogenous leukaemia (CML) myeloid leukemia, chronic chronic myeloid leukaemia CML |
|
| has_related_synonym |
leukemia, chronic myelogenous leukemia, chronic myeloid, atypical leukemia, chronic myeloid |
|
| IAO_0000233 | ||
| id |
EFO:0000339 |
|
| in_subset |
http://purl.obolibrary.org/obo/mondo/mondo-base#rare http://purl.obolibrary.org/obo/mondo#ordo_disease http://purl.obolibrary.org/obo/mondo/mondo-base#otar http://purl.obolibrary.org/obo/mondo/mondo-base#gard_rare http://purl.obolibrary.org/obo/mondo/mondo-base#orphanet_rare http://purl.obolibrary.org/obo/mondo/mondo-base#nord_rare http://purl.obolibrary.org/obo/mondo/mondo-base#ordo_disorder |
|
| label |
chronic myelogenous leukemia |
|
| notation |
EFO:0000339 |
|
| preferred label |
chronic myelogenous leukemia |
|
| prefLabel |
chronic myelogenous leukemia |
|
| skos_closeMatch | ||
| skos_exactMatch |
http://identifiers.org/medgen/75993 http://purl.obolibrary.org/obo/Orphanet_521 http://purl.obolibrary.org/obo/EFO_0000339 http://linkedlifedata.com/resource/umls/id/C0279543 http://purl.obolibrary.org/obo/DOID_8552 |
|
| subClassOf |
http://purl.obolibrary.org/obo/MONDO_0004643 |