loading...| Preferred Name | microglial cell | |
| Synonyms |
MF.microglia.CNS microglia brain macrophage hortega cells microgliocyte brain-resident macrophage |
|
| Definitions |
A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000129 |
|
| comment |
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. |
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| database_cross_reference |
SNOMEDCT:63483002 NIFSTD:sao789292116 BTO:0000078 BTO:0000962 MeSH:D017628 NCIt:C12616 ZFA:0009077 FMA:54539 |
|
| definition |
A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. |
|
| has_broad_synonym |
brain macrophage |
|
| has_exact_synonym |
hortega cells microgliocyte brain-resident macrophage |
|
| has_related_synonym |
MF.microglia.CNS microglia |
|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
|
| label |
microglial cell |
|
| located_in | ||
| preferred label |
microglial cell |
|
| prefixIRI |
CL:0000129 |
|
| prefLabel |
microglial cell |
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| RO_0002175 | ||
| subClassOf |