loading...| Preferred Name |
Central Hypothyroidism |
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| Synonyms |
CellType: thyroid cell PathwayType: signaling Link: https://mammal-profservices.pathwaystudio.com/app/sd?urn=urn:agi-pathway:uuid-fccef23d-1167-4cff-a3b1-947b6df4246c Organ: brain Pathway_Author: A. Nesterova ORCID:0000-0002-9448-8101 Organ: thyroid gland Organ_System: endocrine system CellType: thyrotroph Description: Hypothyroidism is a pathological state caused by the deficiency of thyroid hormones. Pathway is built manually using published studies. PMID: 15481810 NodeType: Pathway CellType: neuron Notes: Headnote: Hypothyroidism is pathological state caused by deficiency of thyroid hormones. Many factors influence synthesis of thyroid hormones, particularly levels of hormones of hypothalamus and pituitary, TRH and TSH are important. Because of that, symptoms of hypothyroidism may significantly vary depending on combination of altered functions of upstream regulators of these hormones. Secondary (central) hypothyroidism accounts for less than 10% of hypothyroidism cases. The causes of it could be a trauma, cancer, other hormones that affect pituitary, or molecular genetic causes (see TSH Release pathway). TRH stimulation testing is used for the differential diagnostics of secondary (pituitary disorder) and tertiary (hypothalamic disorder) hypothyroidism. In hypothyroidism due to pituitary disorder, administration of TRH does not lead to increase in TSH level. Highlighted proteins: Proteins with decreased expression or activity are highlighted in blue, and proteins with increased expression or activity are highlighted in red. PMID: 21062194 Source: Diseases |
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| ID |
urn:agi-pathway:uuid-fccef23d-1167-4cff-a3b1-947b6df4246c |
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| database_cross_reference |
PS:PathwayType PS:Description PS:Pathway_Author PS:Link PS:CellType PS:Organ_System PS:PMID PS:NodeType PS:Notes PS:Organ PS:Source |
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| has_exact_synonym |
CellType: thyroid cell PathwayType: signaling Organ: brain Pathway_Author: A. Nesterova ORCID:0000-0002-9448-8101 Organ: thyroid gland Organ_System: endocrine system CellType: thyrotroph Description: Hypothyroidism is a pathological state caused by the deficiency of thyroid hormones. Pathway is built manually using published studies. PMID: 15481810 NodeType: Pathway CellType: neuron Notes: Headnote: Hypothyroidism is pathological state caused by deficiency of thyroid hormones. Many factors influence synthesis of thyroid hormones, particularly levels of hormones of hypothalamus and pituitary, TRH and TSH are important. Because of that, symptoms of hypothyroidism may significantly vary depending on combination of altered functions of upstream regulators of these hormones. Secondary (central) hypothyroidism accounts for less than 10% of hypothyroidism cases. The causes of it could be a trauma, cancer, other hormones that affect pituitary, or molecular genetic causes (see TSH Release pathway). TRH stimulation testing is used for the differential diagnostics of secondary (pituitary disorder) and tertiary (hypothalamic disorder) hypothyroidism. In hypothyroidism due to pituitary disorder, administration of TRH does not lead to increase in TSH level. Highlighted proteins: Proteins with decreased expression or activity are highlighted in blue, and proteins with increased expression or activity are highlighted in red. PMID: 21062194 Source: Diseases |
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| id |
urn:agi-pathway:uuid-fccef23d-1167-4cff-a3b1-947b6df4246c |
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| label |
Central Hypothyroidism |
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| notation |
uuid-fccef23d-1167-4cff-a3b1-947b6df4246c |
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| prefLabel |
Central Hypothyroidism |
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| treeView |
urn:agi-folder:c urn:agi-folder:endocrine_system urn:agi-folder:hypothyroidism_non-autoimmune |
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| subClassOf |
urn:agi-folder:c urn:agi-folder:endocrine_system urn:agi-folder:hypothyroidism_non-autoimmune |