Preferred Name |
enalaprilat dihydrate |
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Synonyms |
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Definitions |
The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection. |
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ID |
http://purl.obolibrary.org/obo/CHEBI_59877 |
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alternative term |
enalprilate hydrate O.O.C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O InChIKey=MZYVOFLIPYDBGD-MLZQUWKJSA-N enalprilat hydrate C18H28N2O7 enalaprilat InChI=1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1 N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline--water (1/2) 1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate |
|
definition |
The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection. |
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has part | ||
has role | ||
label |
enalaprilat dihydrate |
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prefixIRI |
CHEBI:59877 |
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prefLabel |
enalaprilat dihydrate |
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subClassOf |
Delete | Mapping To | Ontology | Source |
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http://purl.obolibrary.org/obo/CHEBI_59877 | CHEBI | SAME_URI | |
http://purl.obolibrary.org/obo/CHEBI_59877 | DINTO | SAME_URI | |
http://purl.obolibrary.org/obo/CHEBI_59877 | BERO | SAME_URI | |
http://purl.obolibrary.org/obo/CHEBI_59877 | DRON | SAME_URI | |
http://purl.obolibrary.org/obo/CHEBI_59877 | CHEBI | LOOM | |
http://purl.bioontology.org/ontology/NDDF/004369 | NDDF | LOOM | |
http://purl.obolibrary.org/obo/CHEBI_59877 | DINTO | LOOM | |
http://purl.obolibrary.org/obo/CHEBI_59877 | BERO | LOOM |