BioModels Ontology

Last uploaded: April 3, 2012
Preferred Name

enalaprilat dihydrate

Synonyms
Definitions

The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.

ID

http://purl.obolibrary.org/obo/CHEBI_59877

alternative term

enalprilate hydrate

O.O.C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O

InChIKey=MZYVOFLIPYDBGD-MLZQUWKJSA-N

enalprilat hydrate

C18H28N2O7

enalaprilat

InChI=1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1

N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline--water (1/2)

1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate

definition

The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.

has part

http://purl.obolibrary.org/obo/CHEBI_4786

has role

http://purl.obolibrary.org/obo/CHEBI_35674

http://purl.obolibrary.org/obo/CHEBI_35457

label

enalaprilat dihydrate

prefixIRI

CHEBI:59877

prefLabel

enalaprilat dihydrate

subClassOf

http://purl.obolibrary.org/obo/CHEBI_35505

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