loading...| Preferred Name |
cladribine |
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| Synonyms |
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| Definitions |
2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_567361 |
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| alternative term |
Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1 InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N C10H12ClN5O3 (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine 2ClAdo cladribina 2-chloro-2'-deoxy-beta-adenosine InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1 2-chloro-2'-deoxyadenosine cladribinum 2-CdA cladribine 2-chloro-deoxyadenosine 2-chlorodeoxyadenosine CldAdo Cladribine |
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| definition |
2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. |
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| has role | ||
| label |
cladribine |
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| prefixIRI |
CHEBI:567361 |
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| prefLabel |
cladribine |
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| subClassOf |