Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Acitretin | |
| Synonyms |
|
|
| Definitions |
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C985 |
|
| Accepted_Therapeutic_Use_For |
Psoriasis; cutaneous T-cell lymphoma
|
|
| ALT_DEFINITION |
A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids.
|
|
| CAS_Registry |
55079-83-9
|
|
| CHEBI_ID |
CHEBI:50173
|
|
| Chemical_Formula |
C21H26O3
|
|
| code |
C985
|
|
| Contributing_Source |
FDA
|
|
| definition |
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. (NCI04)
|
|
| FDA_UNII_Code |
LCH760E9T7
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Acitretin
|
|
| Legacy Concept Name |
Acitretin
|
|
| Maps_To |
Acitretin
|
|
| NCI_Drug_Dictionary_ID |
43244
|
|
| PDQ_Closed_Trial_Search_ID |
43244
|
|
| PDQ_Open_Trial_Search_ID |
43244
|
|
| Preferred_Name |
Acitretin
|
|
| prefixIRI |
NCIT:C985
|
|
| prefLabel |
Acitretin
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0050559
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping