loading...| Preferred Name |
Decitabine |
|
| Synonyms |
|
|
| Definitions |
A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C981 |
|
| Accepted_Therapeutic_Use_For |
Myelodysplastic Syndrome |
|
| ALT_DEFINITION |
A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It is a type of antimetabolite. |
|
| CAS_Registry |
2353-33-5 |
|
| CHEBI_ID |
CHEBI:50131 |
|
| Chemical_Formula |
C8H12N4O4 |
|
| code |
C981 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04) |
|
| Display_Name |
Decitabine |
|
| FDA_UNII_Code |
776B62CQ27 |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Decitabine |
|
| Legacy Concept Name |
Decitabine |
|
| Maps_To |
Decitabine |
|
| NCI_Drug_Dictionary_ID |
39299 |
|
| NSC Number |
127716 |
|
| PDQ_Closed_Trial_Search_ID |
39299 |
|
| PDQ_Open_Trial_Search_ID |
39299 |
|
| Preferred_Name |
Decitabine |
|
| prefixIRI |
NCIT:C981 |
|
| prefLabel |
Decitabine |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0049065 |
|
| subClassOf |