Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

DNA Methyltransferase Inhibitor
Synonyms
Definitions

Any substance that inhibits DNA methyltransferase, an enzyme required for DNA methylation. Inhibition of DNA methyltransferase results in hypomethylation of genomic DNA and cell cycle arrest at S-phase. Hypomethylation in malignant cells may also restore suppressor gene expression and re-establish controlled growth and differentiation.
ID

http://purl.obolibrary.org/obo/NCIT_C2083
code

C2083
definition

Any substance that inhibits DNA methyltransferase, an enzyme required for DNA methylation. Inhibition of DNA methyltransferase results in hypomethylation of genomic DNA and cell cycle arrest at S-phase. Hypomethylation in malignant cells may also restore suppressor gene expression and re-establish controlled growth and differentiation.
label

DNA Methyltransferase Inhibitor
Legacy Concept Name

DNA_Methyltransferase_Inhibitor
NCI_META_CUI

CL1642980
Preferred_Name

DNA Methyltransferase Inhibitor
prefixIRI

NCIT:C2083
prefLabel

DNA Methyltransferase Inhibitor
Semantic_Type

Chemical Viewed Functionally
subClassOf

http://purl.obolibrary.org/obo/NCIT_C471

http://purl.obolibrary.org/obo/NCIT_C132686
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