Preferred Name

Tofacitinib
Synonyms
Definitions

An orally available inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory activities. Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha and -beta, and may prevent both an inflammatory response and the inflammation-induced damage caused by certain immunological diseases. JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation.

ID

http://purl.obolibrary.org/obo/NCIT_C95800

CAS_Registry

477600-75-2

Chemical_Formula

C16H20N6O

code

C95800

Contributing_Source

FDA

definition

An orally available inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory activities. Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha and -beta, and may prevent both an inflammatory response and the inflammation-induced damage caused by certain immunological diseases. JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation.

FDA_UNII_Code

87LA6FU830

Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C95801

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C173383

http://purl.obolibrary.org/obo/NCIT_C173381

http://purl.obolibrary.org/obo/NCIT_C176424

label

Tofacitinib

NCI_Drug_Dictionary_ID

759505

PDQ_Closed_Trial_Search_ID

759505

PDQ_Open_Trial_Search_ID

759505

Preferred_Name

Tofacitinib

prefixIRI

NCIT:C95800

prefLabel

Tofacitinib

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C2930696

subClassOf

http://purl.obolibrary.org/obo/NCIT_C1967

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