Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Vindesine | |
| Synonyms |
|
|
| Definitions |
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C934 |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.
|
|
| CAS_Registry |
53643-48-4
|
|
| CHEBI_ID |
CHEBI:36373
|
|
| Chemical_Formula |
C43H55N5O7
|
|
| code |
C934
|
|
| Contributing_Source |
FDA
|
|
| definition |
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04)
|
|
| FDA_UNII_Code |
RSA8KO39WH
|
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Vindesine
|
|
| Legacy Concept Name |
Vindesine
|
|
| Maps_To |
Vindesine
|
|
| NCI_Drug_Dictionary_ID |
39732
|
|
| PDQ_Closed_Trial_Search_ID |
39732
|
|
| PDQ_Open_Trial_Search_ID |
39732
|
|
| Preferred_Name |
Vindesine
|
|
| prefixIRI |
NCIT:C934
|
|
| prefLabel |
Vindesine
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0042682
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping