Link to this page
Biological and Environmental Research Ontology
| Preferred Name | Amantadine Sulfate | |
| Synonyms |
|
|
| Definitions |
The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C90781 |
|
| CAS_Registry |
31377-23-8
|
|
| Chemical_Formula |
2C10H17N.H2O4S
|
|
| code |
C90781
|
|
| Contributing_Source |
FDA
|
|
| definition |
The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.
|
|
| FDA_UNII_Code |
9921T5P019
|
|
| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Amantadine Sulfate
|
|
| Preferred_Name |
Amantadine Sulfate
|
|
| prefixIRI |
NCIT:C90781
|
|
| prefLabel |
Amantadine Sulfate
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0002404
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |