loading...| Preferred Name |
Thiotepa |
|
| Synonyms |
|
|
| Definitions |
A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C875 |
|
| Accepted_Therapeutic_Use_For |
Bladder cancer; Breast cancer; Ovarian cancer; Hodgkins lymphoma; Non-hodgkins lymphoma |
|
| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called alkylating agents. |
|
| CAS_Registry |
52-24-4 |
|
| Chemical_Formula |
C6H12N3PS |
|
| code |
C875 |
|
| Contributing_Source |
CTRP FDA PCDC |
|
| definition |
A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. |
|
| Display_Name |
Thiotepa |
|
| FDA_UNII_Code |
905Z5W3GKH |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C174019 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 |
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| Is_PCDC_AML_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Thiotepa |
|
| Legacy Concept Name |
Thiotepa |
|
| Maps_To |
Thiotepa |
|
| NCI_Drug_Dictionary_ID |
42933 |
|
| NSC Number |
6396 |
|
| PDQ_Closed_Trial_Search_ID |
42933 |
|
| PDQ_Open_Trial_Search_ID |
42933 |
|
| Preferred_Name |
Thiotepa |
|
| prefixIRI |
NCIT:C875 |
|
| prefLabel |
Thiotepa |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0039871 |
|
| subClassOf |