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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Teniposide | |
| Synonyms |
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| Definitions |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C857 |
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| ALT_DEFINITION |
An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors.
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| CAS_Registry |
29767-20-2
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| Chemical_Formula |
C32H32O13S
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| code |
C857
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| Contributing_Source |
CTRP FDA
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| definition |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)
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| Display_Name |
Teniposide
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| FDA_UNII_Code |
957E6438QA
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Teniposide
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| Legacy Concept Name |
Teniposide
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| Maps_To |
Teniposide
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| NCI_Drug_Dictionary_ID |
43671
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| NSC Number |
122819
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| PDQ_Closed_Trial_Search_ID |
43671
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| PDQ_Open_Trial_Search_ID |
43671
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| Preferred_Name |
Teniposide
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| prefixIRI |
NCIT:C857
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| prefLabel |
Teniposide
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0039512
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| subClassOf |
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