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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Lomitapide | |
| Synonyms |
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| Definitions |
A small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein. Inhibition of MTP by lomitapide blocks transfer of lipid to apo-B, and as a result emerging apo-B is destroyed and lipoprotein secretion is inhibited. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C83891 |
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| CAS_Registry |
182431-12-5
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| Chemical_Formula |
C39H37F6N3O2
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| code |
C83891
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| Contributing_Source |
FDA
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|
| definition |
A small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein. Inhibition of MTP by lomitapide blocks transfer of lipid to apo-B, and as a result emerging apo-B is destroyed and lipoprotein secretion is inhibited.
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| FDA_UNII_Code |
82KUB0583F
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Lomitapide
|
|
| Preferred_Name |
Lomitapide
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| prefixIRI |
NCIT:C83891
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| prefLabel |
Lomitapide
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C2827241
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| subClassOf |
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