Preferred Name

Betahistine
Synonyms
Definitions

A histamine analog with weak histamine H1 agonistic and more potent histamine H3 antagonistic properties. Upon intranasal administration, betahistine binds to histamine H1 and H3 receptors and exerts its agonistic and antagonistic actions locally and centrally. This promotes cochlear, vestibular and cerebral blood flow, decreases neuronal firing in the vestibular nuclei and increases histamine synthesis and release in the brain which facilitates vestibular compensation. Increased blood flow around the inner ear reduces the amount of fluid in the inner ear and may alleviate vertigo, tinnitus, and hearing loss.

ID

http://purl.obolibrary.org/obo/NCIT_C83554

CAS_Registry

5638-76-6

CHEBI_ID

CHEBI:35677

Chemical_Formula

C8H12N2

code

C83554

Contributing_Source

FDA

definition

A histamine analog with weak histamine H1 agonistic and more potent histamine H3 antagonistic properties. Upon intranasal administration, betahistine binds to histamine H1 and H3 receptors and exerts its agonistic and antagonistic actions locally and centrally. This promotes cochlear, vestibular and cerebral blood flow, decreases neuronal firing in the vestibular nuclei and increases histamine synthesis and release in the brain which facilitates vestibular compensation. Increased blood flow around the inner ear reduces the amount of fluid in the inner ear and may alleviate vertigo, tinnitus, and hearing loss.

FDA_UNII_Code

X32KK4201D

Has_Salt_Form

http://purl.obolibrary.org/obo/NCIT_C73794

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

label

Betahistine

Preferred_Name

Betahistine

prefixIRI

NCIT:C83554

prefLabel

Betahistine

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0005301

subClassOf

http://purl.obolibrary.org/obo/NCIT_C29707

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