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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Prasugrel | |
| Synonyms |
|
|
| Definitions |
An orally bioavailable thienopyridine, with antiplatelet activity. Upon oral administration, the active metabolite of prasugrel targets and irreversibly binds to the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor. This inhibits ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C81566 |
|
| CAS_Registry |
150322-43-3
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|
| Chemical_Formula |
C20H20FNO3S
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|
| code |
C81566
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
An orally bioavailable thienopyridine, with antiplatelet activity. Upon oral administration, the active metabolite of prasugrel targets and irreversibly binds to the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor. This inhibits ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time.
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| Display_Name |
Prasugrel
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|
| FDA_UNII_Code |
34K66TBT99
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|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 |
|
| label |
Prasugrel
|
|
| Legacy Concept Name |
Prasugrel
|
|
| Preferred_Name |
Prasugrel
|
|
| prefixIRI |
NCIT:C81566
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|
| prefLabel |
Prasugrel
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|
| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C1620287
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| subClassOf |
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