Preferred Name

Razoxane

Synonyms
Definitions

An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically inhibits the enzyme topoisomerase II without inducing DNA strand breaks, which may result in the inhibition of DNA synthesis and cell division in the premitotic and early mitotic phases of the cell cycle. This agent may also exhibit antiangiogenic and antimetastatic activities although the precise molecular mechanisms of these actions are unknown.

ID

http://purl.obolibrary.org/obo/NCIT_C801

CAS_Registry

21416-67-1

21416-87-5

CHEBI_ID

CHEBI:50225

Chemical_Formula

C11H16N4O4

code

C801

Contributing_Source

FDA

definition

An orally bioavailable bis-dioxopiperazine and a derivative of the chelating agent ethylenediaminetetraacetic acid (EDTA) with antineoplastic, antiangiogenic, and antimetastatic activities. Razoxane specifically inhibits the enzyme topoisomerase II without inducing DNA strand breaks, which may result in the inhibition of DNA synthesis and cell division in the premitotic and early mitotic phases of the cell cycle. This agent may also exhibit antiangiogenic and antimetastatic activities although the precise molecular mechanisms of these actions are unknown.

FDA_UNII_Code

5AR83PR647

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712

Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909

label

Razoxane

Legacy Concept Name

Razoxane

Maps_To

Razoxane

NCI_Drug_Dictionary_ID

39480

NSC Number

129943

PDQ_Closed_Trial_Search_ID

39480

PDQ_Open_Trial_Search_ID

39480

Preferred_Name

Razoxane

prefixIRI

NCIT:C801

prefLabel

Razoxane

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0034738

subClassOf

http://purl.obolibrary.org/obo/NCIT_C360

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