loading...| Preferred Name |
Copper Gluconate |
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| Synonyms |
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| Definitions |
The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C80050 |
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| CAS_Registry |
527-09-3 |
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| Chemical_Formula |
2C6H11O7.Cu |
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| code |
C80050 |
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| Contributing_Source |
CTRP FDA |
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| definition |
The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations. |
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| Display_Name |
Copper Gluconate |
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| FDA_UNII_Code |
RV823G6G67 |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Copper Gluconate |
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| Legacy Concept Name |
Copper_Gluconate |
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| Maps_To |
Copper Gluconate |
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| NCI_Drug_Dictionary_ID |
614606 |
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| PDQ_Closed_Trial_Search_ID |
614606 |
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| PDQ_Open_Trial_Search_ID |
614606 |
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| Preferred_Name |
Copper Gluconate |
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| prefixIRI |
NCIT:C80050 |
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| prefLabel |
Copper Gluconate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0982097 |
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| subClassOf |