Preferred Name

Copper Gluconate
Synonyms
Definitions

The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations.

ID

http://purl.obolibrary.org/obo/NCIT_C80050

CAS_Registry

527-09-3

Chemical_Formula

2C6H11O7.Cu

code

C80050

Contributing_Source

CTRP

FDA

definition

The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations.

Display_Name

Copper Gluconate

FDA_UNII_Code

RV823G6G67

Has_Target

http://purl.obolibrary.org/obo/NCIT_C13970

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712

Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909

label

Copper Gluconate

Legacy Concept Name

Copper_Gluconate

Maps_To

Copper Gluconate

NCI_Drug_Dictionary_ID

614606

PDQ_Closed_Trial_Search_ID

614606

PDQ_Open_Trial_Search_ID

614606

Preferred_Name

Copper Gluconate

prefixIRI

NCIT:C80050

prefLabel

Copper Gluconate

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0982097

subClassOf

http://purl.obolibrary.org/obo/NCIT_C1505

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