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Biological and Environmental Research Ontology
| Preferred Name | Procarbazine Hydrochloride | |
| Synonyms |
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| Definitions |
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C773 |
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| Accepted_Therapeutic_Use_For |
Brain tumors; Hodgkins diseases; Non-Hodgkins lymphoma
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| ALT_DEFINITION |
A drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Matulane blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.
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| CAS_Registry |
366-70-1
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| Chemical_Formula |
C12H19N3O.HCl
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| code |
C773
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| Contributing_Source |
CTRP FDA
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| definition |
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
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| Display_Name |
Procarbazine Hydrochloride
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| FDA_UNII_Code |
XH0NPH5ZX8
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Procarbazine Hydrochloride
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| Legacy Concept Name |
Procarbazine
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| Maps_To |
Procarbazine Hydrochloride
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| NCI_Drug_Dictionary_ID |
41607
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| NSC Number |
77213
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| PDQ_Closed_Trial_Search_ID |
41607
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| PDQ_Open_Trial_Search_ID |
41607
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| Preferred_Name |
Procarbazine Hydrochloride
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| prefixIRI |
NCIT:C773
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| prefLabel |
Procarbazine Hydrochloride
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0205909
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| subClassOf |
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