loading...| Preferred Name |
Tirofiban |
|
| Synonyms |
|
|
| Definitions |
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C76405 |
|
| CAS_Registry |
144494-65-5 |
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| CHEBI_ID |
CHEBI:9605 |
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| Chemical_Formula |
C22H36N2O5S |
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| code |
C76405 |
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| Contributing_Source |
FDA |
|
| definition |
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time. |
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| FDA_UNII_Code |
GGX234SI5H |
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Tirofiban |
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| Legacy Concept Name |
Tirofiban |
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| Preferred_Name |
Tirofiban |
|
| prefixIRI |
NCIT:C76405 |
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| prefLabel |
Tirofiban |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0247025 |
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| subClassOf |