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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Tirofiban | |
| Synonyms |
|
|
| Definitions |
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C76405 |
|
| CAS_Registry |
144494-65-5
|
|
| CHEBI_ID |
CHEBI:9605
|
|
| Chemical_Formula |
C22H36N2O5S
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|
| code |
C76405
|
|
| Contributing_Source |
FDA
|
|
| definition |
A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time.
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|
| FDA_UNII_Code |
GGX234SI5H
|
|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Tirofiban
|
|
| Legacy Concept Name |
Tirofiban
|
|
| Preferred_Name |
Tirofiban
|
|
| prefixIRI |
NCIT:C76405
|
|
| prefLabel |
Tirofiban
|
|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0247025
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|
| subClassOf |
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