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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Ticagrelor | |
| Synonyms |
|
|
| Definitions |
An orally bioavailable cyclopentyltriazolopyrimidine, with antiplatelet activity. Upon oral administration, ticagrelor and its major metabolite targets and reversibly binds to the platelet adenosine diphosphate (ADP) P2Y12 receptor (P2Y12R) at a site distinct from that of the endogenous agonist ADP. This blocks the platelet signaling pathway, thereby inhibiting the activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C76404 |
|
| Accepted_Therapeutic_Use_For |
Acute Coronary Syndrome
|
|
| CAS_Registry |
274693-27-5
|
|
| Chemical_Formula |
C23H28F2N6O4S
|
|
| code |
C76404
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
An orally bioavailable cyclopentyltriazolopyrimidine, with antiplatelet activity. Upon oral administration, ticagrelor and its major metabolite targets and reversibly binds to the platelet adenosine diphosphate (ADP) P2Y12 receptor (P2Y12R) at a site distinct from that of the endogenous agonist ADP. This blocks the platelet signaling pathway, thereby inhibiting the activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation.
|
|
| Display_Name |
Ticagrelor
|
|
| FDA_UNII_Code |
GLH0314RVC
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 |
|
| label |
Ticagrelor
|
|
| Legacy Concept Name |
Ticagrelor
|
|
| Preferred_Name |
Ticagrelor
|
|
| prefixIRI |
NCIT:C76404
|
|
| prefLabel |
Ticagrelor
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C1999375
|
|
| subClassOf |
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