Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Jump to:
Preferred Name

Cilazapril Anhydrous
Synonyms
Definitions

The anhydrous form of the pyridazine angiotensin-converting enzyme (ACE) inhibitor cilazapril with antihypertensive activity. As a prodrug cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
ID

http://purl.obolibrary.org/obo/NCIT_C76134
CAS_Registry

88768-40-5
Chemical_Formula

C22H31N3O5
code

C76134
Contributing_Source

FDA
definition

The anhydrous form of the pyridazine angiotensin-converting enzyme (ACE) inhibitor cilazapril with antihypertensive activity. As a prodrug cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
FDA_UNII_Code

8Q9454114Q
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Cilazapril Anhydrous
Legacy Concept Name

Cilazapril_Anhydrous
Preferred_Name

Cilazapril Anhydrous
prefixIRI

NCIT:C76134
prefLabel

Cilazapril Anhydrous
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0886706
subClassOf

http://purl.obolibrary.org/obo/NCIT_C247
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display