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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Sertaconazole | |
| Synonyms |
|
|
| Definitions |
A synthetic imidazole derivative, containing a benzothiophene ring, with antifungal, antibacterial, anti-inflammatory and anti-pruritic activity. Besides its ability to inhibit the synthesis of ergosterol, the benzothiophene ring of sertaconazole is able to insert into the fungal cell wall instead of tryptophan. This increases the permeability of the cell wall. In addition, sertaconazole suppresses the release of cytokines. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C75206 |
|
| CAS_Registry |
99592-32-2
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| Chemical_Formula |
C20H15Cl3N2OS
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|
| code |
C75206
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|
| Contributing_Source |
FDA
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|
| definition |
A synthetic imidazole derivative, containing a benzothiophene ring, with antifungal, antibacterial, anti-inflammatory and anti-pruritic activity. Besides its ability to inhibit the synthesis of ergosterol, the benzothiophene ring of sertaconazole is able to insert into the fungal cell wall instead of tryptophan. This increases the permeability of the cell wall. In addition, sertaconazole suppresses the release of cytokines.
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| FDA_UNII_Code |
72W71I16EG
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Sertaconazole
|
|
| Legacy Concept Name |
Sertaconazole
|
|
| Preferred_Name |
Sertaconazole
|
|
| prefixIRI |
NCIT:C75206
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| prefLabel |
Sertaconazole
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0074391
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| subClassOf |
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