loading...| Preferred Name | Alpha-Tocopherol | |
| Synonyms |
|
|
| Definitions |
The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C74960 |
|
| ALT_DEFINITION |
Tocopherol with three methyl groups on its chromanol ring. |
|
| CAS_Registry |
59-02-9 |
|
| CHEBI_ID |
CHEBI:18145 |
|
| Chemical_Formula |
C29H50O2 |
|
| code |
C74960 |
|
| Contributing_Source |
CRCH CTRP FDA |
|
| definition |
The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body. |
|
| Display_Name |
Alpha-Tocopherol |
|
| FDA_UNII_Code |
H4N855PNZ1 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| INFOODS |
TOCPHA |
|
| label |
Alpha-Tocopherol |
|
| Legacy Concept Name |
Alpha-Tocopherol |
|
| Macronutrient |
Y |
|
| NCI_Drug_Dictionary_ID |
775583 |
|
| NCI_META_CUI |
CL938214 |
|
| NSC Number |
20812 |
|
| Nutrient |
Y |
|
| PDQ_Closed_Trial_Search_ID |
775583 |
|
| PDQ_Open_Trial_Search_ID |
775583 |
|
| Preferred_Name |
Alpha-Tocopherol |
|
| prefixIRI |
NCIT:C74960 |
|
| prefLabel |
Alpha-Tocopherol |
|
| Semantic_Type |
Pharmacologic Substance Vitamin |
|
| Unit |
mg |
|
| USDA_ID |
323 |
|
| subClassOf |